Karigane Daiki, Takubo Keiyo
Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.
Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Int J Hematol. 2017 Jul;106(1):18-26. doi: 10.1007/s12185-017-2261-x. Epub 2017 May 24.
Hematopoietic stem cells (HSCs) exhibit multilineage differentiation and self-renewal activities that maintain the entire hematopoietic system during an organism's lifetime. These abilities are sustained by intrinsic transcriptional programs and extrinsic cues from the microenvironment or niche. Recent studies using metabolomics technologies reveal that metabolic regulation plays an essential role in HSC maintenance. Metabolic pathways provide energy and building blocks for other factors functioning at steady state and in stress. Here we review recent advances in our understanding of metabolic regulation in HSCs relevant to cell cycle quiescence, symmetric/asymmetric division, and proliferation following stress and lineage commitment, and discuss the therapeutic potential of targeting metabolic factors or pathways to treat hematological malignancies.
造血干细胞（HSCs）具有多谱系分化和自我更新能力，在生物体的一生中维持整个造血系统。这些能力由内在转录程序以及来自微环境或生态位的外在信号所维持。最近使用代谢组学技术的研究表明，代谢调节在造血干细胞的维持中起着至关重要的作用。代谢途径为在稳态和应激状态下起作用的其他因子提供能量和构件。在这里，我们综述了在理解与细胞周期静止、对称/不对称分裂以及应激和谱系定向后的增殖相关的造血干细胞代谢调节方面的最新进展，并讨论了靶向代谢因子或途径治疗血液系统恶性肿瘤的治疗潜力。
