Lee Suk Jeong, Son Heesook, Shin Sug Kyun
Red Cross College of Nursing, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, South Korea.
National Health Insurance Cooperation Ilsan Hospital Clinical Professor, Yonsei University Medical College, Seoul, South Korea.
Health Qual Life Outcomes. 2015 May 29;13:70. doi: 10.1186/s12955-015-0270-0.
Chronic kidney disease (CKD) is a progressive and lifelong condition with multiple medical comorbidities. Patients with CKD experience frailty more frequently and have lower health-related quality of life than do those with other chronic diseases. The purpose of this study was to examine the prevalence of frailty and investigate the contribution of frailty to quality of life in pre-dialysis CKD patients in Korea.
Using a cross-sectional survey design, data were collected at an outpatient CKD clinic in a general hospital in Korea. The frailty criterion was modified from previous studies. The Short Form-36 Health Survey version 2 was used to measure physical and mental component summary scores. Data were analyzed using chi-square, t-tests, and hierarchical linear regression.
Of the 168 CKD patients, 63 (37.5 %) were frail. Frail patients were significantly older and had lower physical and mental quality of life than those who were non-frail. In hierarchical regression evaluating the influence of frailty on physical and mental quality of life, the initial model was significantly improved when frailty was included. Frail patients had lower physical and mental quality of life.
Frailty affected both physical and mental quality of life in pre-dialysis patients with CKD. More attention should be paid to the potential role of early detection and prevention of frailty to improve patients' quality of life.
慢性肾脏病（CKD）是一种具有多种合并症的进行性终身疾病。与其他慢性疾病患者相比，CKD患者更频繁地出现身体虚弱，且健康相关生活质量较低。本研究的目的是调查韩国透析前CKD患者身体虚弱的患病率，并探讨身体虚弱对生活质量的影响。
采用横断面调查设计，在韩国一家综合医院的门诊CKD诊所收集数据。身体虚弱标准是根据以往研究修改而来。使用简式36健康调查第2版来测量身体和心理综合得分。数据采用卡方检验、t检验和分层线性回归进行分析。
168例CKD患者中，63例（37.5%）身体虚弱。身体虚弱的患者年龄显著更大，身体和心理生活质量低于非身体虚弱患者。在评估身体虚弱对身体和心理生活质量影响的分层回归中，纳入身体虚弱因素后初始模型有显著改善。身体虚弱的患者身体和心理生活质量较低。
身体虚弱影响透析前CKD患者的身体和心理生活质量。应更加关注早期发现和预防身体虚弱对改善患者生活质量的潜在作用。
