Mansur Henrique Novais, Colugnati Fernando Ab, Grincenkov Fabiane Rossi Dos Santos, Bastos Marcus Gomes
Health Qual Life Outcomes. 2014 Feb 28;12:27. doi: 10.1186/1477-7525-12-27.
Chronic kidney disease (CKD) induces frailty and worsens quality of life (QOL), even in the early stages of the disease and in young patients. However, there is a lack of knowledge about the relationship between frailty and QOL in CKD patients. Thus, we investigated this relationship in a sample of CKD patients.
A cross-observational study was conducted, in which 61 CKD patients receiving pre-dialysis treatment were assessed. All participants completed the Short Form-36 Health Survey (SF-36). We used valid and reliable methods to classify subjects as frail or non-frail according to Johansen's et al. (2007) criteria. A one-way analysis of variance (ANOVA) and chi-square tests were used to compare the groups. In addition, Spearman's correlation analysis was conducted to measure associations between identified variables and frailty. We also performed simple linear regression using the SF-36 physical and mental composite scores.
Almost half of the sample (42.6%) exhibited evidence of frailty. The groups differed significantly in terms of age, gender, and all SF-36 domains, excluding Social Functioning and Role Emotional. Frailty was significantly associated with all SF-36 domains, again excluding Social Functioning and Role Emotional. Regression analysis revealed no significant between-group differences in composite physical and mental health scores generated by the SF-36 (p > 0.05).
Frail and non-frail CKD patients differed significantly in seven of the eight SF-36 domains. The frail group displayed diminished physical and mental functioning when their SF-36 scores were divided by their physical and mental composite scores. Frailty was correlated with QOL domains, with the exception of the social domain. There is a need for interventions targeting the characteristics of frailty, to provide better treatment and optimize overall QOL.
慢性肾脏病（CKD）会导致身体虚弱并降低生活质量（QOL），即使在疾病早期和年轻患者中也是如此。然而，对于CKD患者身体虚弱与生活质量之间的关系，我们了解甚少。因此，我们在一组CKD患者样本中研究了这种关系。
进行了一项横断面观察研究，评估了61名接受透析前治疗的CKD患者。所有参与者都完成了简短健康调查问卷（SF-36）。我们采用有效且可靠的方法，根据约翰森等人（2007年）的标准将受试者分为身体虚弱或非虚弱两类。使用单因素方差分析（ANOVA）和卡方检验来比较各组。此外，进行了斯皮尔曼相关性分析，以测量已识别变量与身体虚弱之间的关联。我们还使用SF-36身体和心理综合评分进行了简单线性回归分析。
几乎一半的样本（42.6%）表现出身体虚弱的迹象。除社会功能和情感角色外，各组在年龄、性别和所有SF-36领域方面存在显著差异。身体虚弱与所有SF-36领域均显著相关，同样不包括社会功能和情感角色。回归分析显示，SF-36产生的综合身体和心理健康评分在组间无显著差异（p>0.05）。
虚弱和非虚弱的CKD患者在八个SF-36领域中的七个领域存在显著差异。当根据身体和心理综合评分对SF-36评分进行划分时，虚弱组的身体和心理功能有所下降。身体虚弱与生活质量领域相关，但社会领域除外。需要针对身体虚弱的特征进行干预，以提供更好的治疗并优化整体生活质量。
