Kucharska Anna M, Pyrżak Beata, Demkow Urszula
Department of Pediatrics and Endocrinology, Medical University of Warsaw, 24 Marszalkowska St., 00-576, Warsaw, Poland,
Adv Exp Med Biol. 2015;866:35-40. doi: 10.1007/5584_2015_147.
The current concept of the pathogenesis of obesity relates to the inflammation caused by excess of adipose tissue. Regulatory T cells accumulated in visceral adipose tissue (VAT-resident Tregs) are also involved in this pathogenesis. In the present paper the mechanisms responsible for alterations in the number and function of VAT-resident Tregs T in obesity are described. The role of Tregs in inflammation, insulin resistance, atherogenesis, and also the influence on VAT-resident Tregs of adipocytokines and insulin are reviewed.
当前肥胖发病机制的概念与脂肪组织过多引起的炎症有关。在内脏脂肪组织中积累的调节性T细胞（内脏脂肪组织驻留调节性T细胞）也参与了这一发病机制。本文描述了肥胖状态下内脏脂肪组织驻留调节性T细胞数量和功能改变的相关机制。综述了调节性T细胞在炎症、胰岛素抵抗、动脉粥样硬化形成中的作用，以及脂肪细胞因子和胰岛素对内脏脂肪组织驻留调节性T细胞的影响。
