Ghanemi Abdelaziz, Yoshioka Mayumi, St-Amand Jonny
Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Québec, QC G1V 4G2, Canada.
Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada.
Medicines (Basel). 2021 Oct 8;8(10):57. doi: 10.3390/medicines8100057.
Obesity represents a risk factor for a variety of diseases because of its inflammatory component, among other biological patterns. Recently, with the ongoing COVID-19 crisis, a special focus has been put on obesity as a status in which antibody production, among other immune functions, is impaired, which would impact both disease pathogenesis and vaccine efficacy. Within this piece of writing, we illustrate that such patterns would be due to the increased adiposity and fat distribution pattern rather than obesity (as defined by the body mass index) itself. Within this context, we also highlight the importance of the weight-loss-independent effects of exercise.
肥胖因其炎症成分以及其他生物学特征，是多种疾病的危险因素。最近，随着新冠疫情的持续，肥胖作为一种抗体产生及其他免疫功能受损的状态受到了特别关注，这会影响疾病的发病机制和疫苗效力。在本文中，我们阐明这些特征是由于肥胖程度增加和脂肪分布模式所致，而非肥胖本身（如由体重指数所定义）。在此背景下，我们还强调了运动对体重减轻无依赖作用的重要性。
