Rangamani Sukanya, SathishKumar Krishnan, Manoharan N, Julka Pramod Kumar, Rath Goura Kishor, Shanta Viswanathan, Swaminathan Rajaraman, Rama Ranganathan, Datta Karabi, Mandal Syamsundar, Koyande Shravani, Deshmane Vinay, Ganesh B, Banavali Shripad D, Badwe Rajendra A, Ramesh C, Appaji Lingappa, Nandakumar Ambakumar
National Centre for Disease Informatics and Research, Indian Council of Medical Research, India E-mail :
Asian Pac J Cancer Prev. 2015;16(10):4193-8. doi: 10.7314/apjcp.2015.16.10.4193.
Globally, retinoblastoma is the most common primary intraocular malignancy occurring in children. This paper documents the recent incidence rates of retinoblastoma by age and sex groups from the Population Based Cancer Registries (PBCRs) of Bangalore, Mumbai, Chennai, Delhi and Kolkata using the data from the National Cancer Registry Programme.
Relative proportions, sex ratio, method of diagnosis, and incidence rates (crude and age standardized) for each PBCR and pooled rates of the five PBCRs were calculated for the years 2005/06 to 2009/10. Standard errors and 95% confidence limits of ASIRs by sex group in each PBCR were calculated using the Poisson distribution. Standardised rate ratios of ASIR by sex group and rate ratios at risk were also calculated.
The maximum retinoblastoma cases were in the 0-4 age group, accounting for 78% (females) and 81% (males) of pooled cases from five PBCRs. The pooled crude incidence rate in the 0-14 age group was 3.5 and the pooled ASIR was 4.4 per million. The pooled ASIR in the 0-4, 5-9 and 10-14 age group were 9.6, 2.0 and 0.1 respectively. The M/F ratio in Chennai (1.9) and Bangalore PBCRs (2.0) was much higher than the other PBCRs. Among the PBCRs, the highest incidence rate in 0-4 age group was found in males in Chennai (21.7 per million), and females in Kolkata (18.9 per million). There was a distinct variation in incidence rates in the PBCRs in different geographic regions of India.
在全球范围内，视网膜母细胞瘤是儿童中最常见的原发性眼内恶性肿瘤。本文利用国家癌症登记计划的数据，记录了班加罗尔、孟买、钦奈、德里和加尔各答基于人群的癌症登记处（PBCRs）按年龄和性别分组的视网膜母细胞瘤近期发病率。
计算了2005/06年至2009/10年期间每个PBCR的相对比例、性别比、诊断方法以及发病率（粗发病率和年龄标准化发病率），并计算了五个PBCR的合并发病率。使用泊松分布计算每个PBCR中按性别分组的年龄标准化发病率（ASIRs）的标准误差和95%置信区间。还计算了按性别分组的ASIR标准化率比和风险率比。
视网膜母细胞瘤病例最多的是0 - 4岁年龄组，占五个PBCR合并病例的78%（女性）和81%（男性）。0 - 14岁年龄组的合并粗发病率为3.5，合并ASIR为每百万4.4。0 - 4岁、5 - 9岁和10 - 14岁年龄组的合并ASIR分别为9.6、2.0和0.1。钦奈（1.9）和班加罗尔PBCR（2.0）的男/女比例远高于其他PBCR。在各PBCR中，0 - 4岁年龄组发病率最高的是钦奈的男性（每百万21.7）和加尔各答的女性（每百万18.9）。印度不同地理区域的PBCR发病率存在明显差异。
