Ariza Pedro, Solesio-Jofre Elena, Martínez Johann H, Pineda-Pardo José A, Niso Guiomar, Maestú Fernando, Buldú Javier M
Laboratory of Biological Networks, Centre for Biomedical Technology, Technical University of Madrid Madrid, Spain.
Department of Basic Psychology, Universidad Autónoma de Madrid Madrid, Spain.
Front Hum Neurosci. 2015 May 12;9:255. doi: 10.3389/fnhum.2015.00255. eCollection 2015.
In this study we used graph theory analysis to investigate age-related reorganization of functional networks during the active maintenance of information that is interrupted by external interference. Additionally, we sought to investigate network differences before and after averaging network parameters between both maintenance and interference windows. We compared young and older adults by measuring their magnetoencephalographic recordings during an interference-based working memory task restricted to successful recognitions. Data analysis focused on the topology/temporal evolution of functional networks during both the maintenance and interference windows. We observed that: (a) Older adults require higher synchronization between cortical brain sites in order to achieve a successful recognition, (b) The main differences between age groups arise during the interference window,
在本研究中，我们使用图论分析来研究在信息的主动维持过程中，当信息被外部干扰打断时，功能网络与年龄相关的重组情况。此外，我们试图研究在对维持窗口和干扰窗口的网络参数进行平均前后的网络差异。我们通过测量年轻人和老年人在基于干扰的工作记忆任务（仅限于成功识别）期间的脑磁图记录来进行比较。数据分析聚焦于维持窗口和干扰窗口期间功能网络的拓扑结构/时间演变。我们观察到：（a）老年人为了实现成功识别，需要在大脑皮质位点之间有更高的同步性；（b）年龄组之间的主要差异出现在干扰窗口期间。
