• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

抗菌药物耐药性的全球威胁:干预科学

The global threat of antimicrobial resistance: science for intervention.

作者信息

Roca I, Akova M, Baquero F, Carlet J, Cavaleri M, Coenen S, Cohen J, Findlay D, Gyssens I, Heuer O E, Kahlmeter G, Kruse H, Laxminarayan R, Liébana E, López-Cerero L, MacGowan A, Martins M, Rodríguez-Baño J, Rolain J-M, Segovia C, Sigauque B, Tacconelli E, Wellington E, Vila J

机构信息

ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.

Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, Ankara, Turkey ; ESCMID Executive Committee, Basel, Switzerland.

出版信息

New Microbes New Infect. 2015 Apr 16;6:22-9. doi: 10.1016/j.nmni.2015.02.007. eCollection 2015 Jul.

DOI:10.1016/j.nmni.2015.02.007
PMID:26029375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4446399/
Abstract

In the last decade we have witnessed a dramatic increase in the proportion and absolute number of bacterial pathogens resistant to multiple antibacterial agents. Multidrug-resistant bacteria are currently considered as an emergent global disease and a major public health problem. The B-Debate meeting brought together renowned experts representing the main stakeholders (i.e. policy makers, public health authorities, regulatory agencies, pharmaceutical companies and the scientific community at large) to review the global threat of antibiotic resistance and come up with a coordinated set of strategies to fight antimicrobial resistance in a multifaceted approach. We summarize the views of the B-Debate participants regarding the current situation of antimicrobial resistance in animals and the food chain, within the community and the healthcare setting as well as the role of the environment and the development of novel diagnostic and therapeutic strategies, providing expert recommendations to tackle the global threat of antimicrobial resistance.

摘要

在过去十年中,我们目睹了对多种抗菌药物耐药的细菌病原体比例和绝对数量的急剧增加。耐多药细菌目前被视为一种新出现的全球疾病和一个主要的公共卫生问题。B-Debate会议汇聚了代表主要利益相关者(即政策制定者、公共卫生当局、监管机构、制药公司和广大科学界)的知名专家,以审视抗生素耐药性的全球威胁,并提出一套协调一致的策略,以多方面的方法对抗抗菌药物耐药性。我们总结了B-Debate参与者对于动物和食物链、社区以及医疗环境中抗菌药物耐药性现状的看法,以及环境的作用和新型诊断与治疗策略的发展情况,提供了应对抗菌药物耐药性全球威胁的专家建议。

相似文献

1
The global threat of antimicrobial resistance: science for intervention.抗菌药物耐药性的全球威胁:干预科学
New Microbes New Infect. 2015 Apr 16;6:22-9. doi: 10.1016/j.nmni.2015.02.007. eCollection 2015 Jul.
2
A narrative review on drug development for the management of antimicrobial- resistant infection crisis in Japan: the past, present, and future.一篇关于日本管理抗生素耐药性感染危机的药物开发的叙事性综述:过去、现在和未来。
Expert Rev Anti Infect Ther. 2022 Dec;20(12):1603-1614. doi: 10.1080/14787210.2022.2142118. Epub 2022 Nov 15.
3
Tackling Threats and Future Problems of Multidrug-Resistant Bacteria.应对多重耐药菌的威胁及未来问题
Curr Top Microbiol Immunol. 2016;398:3-33. doi: 10.1007/82_2016_492.
4
5
Clinical pharmacology of antimicrobial use in humans and animals.人类和动物抗菌药物使用的临床药理学
J Clin Pharmacol. 2002 Jun;42(6):587-600. doi: 10.1177/00970002042006001.
6
Less Is More: Norwegian Drug Regulation, Antibiotic Policy, and the "Need Clause".少即是多:挪威的药品监管、抗生素政策与“需求条款”。
Milbank Q. 2019 Sep;97(3):762-795. doi: 10.1111/1468-0009.12405. Epub 2019 Jul 21.
7
Impact of antibiotic use in adult dairy cows on antimicrobial resistance of veterinary and human pathogens: a comprehensive review.抗生素在成年奶牛中的使用对兽医和人源病原体的抗药性的影响:全面综述。
Foodborne Pathog Dis. 2011 Mar;8(3):337-55. doi: 10.1089/fpd.2010.0730. Epub 2010 Dec 6.
8
Antibiotic resistant bacteria: current situation and treatment options to accelerate the development of a new antimicrobial arsenal.抗生素耐药菌:现状与治疗选择,以加速新抗菌药物的研发。
Expert Rev Anti Infect Ther. 2022 Aug;20(8):1095-1108. doi: 10.1080/14787210.2022.2078308. Epub 2022 May 31.
9
The challenges of multi-drug-resistance in hepatology.肝医学领域的多药耐药挑战。
J Hepatol. 2016 Nov;65(5):1043-1054. doi: 10.1016/j.jhep.2016.08.006. Epub 2016 Aug 17.
10
Treatment of infections caused by multidrug-resistant Gram-negative bacteria: report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party.治疗多重耐药革兰氏阴性菌引起的感染:英国抗菌化疗学会/医疗保健感染学会/英国感染协会联合工作组的报告。
J Antimicrob Chemother. 2018 Mar 1;73(suppl_3):iii2-iii78. doi: 10.1093/jac/dky027.

引用本文的文献

1
Genomic Epidemiology of ESBL- and Carbapenemase-Producing Enterobacterales in a Spanish Hospital: Exploring the Clinical-Environmental Interface.西班牙一家医院产超广谱β-内酰胺酶和碳青霉烯酶肠杆菌科细菌的基因组流行病学:探索临床-环境界面
Microorganisms. 2025 Aug 8;13(8):1854. doi: 10.3390/microorganisms13081854.
2
Synthesis and Antibacterial Evaluation of an Indole Triazole Conjugate with In Silico Evidence of Allosteric Binding to Penicillin-Binding Protein 2a.一种吲哚三唑缀合物的合成及其抗菌评估:对青霉素结合蛋白2a变构结合的计算机模拟证据
Pharmaceutics. 2025 Aug 3;17(8):1013. doi: 10.3390/pharmaceutics17081013.
3
In Vitro and In Vivo Characterization of Novel Cathelicidin-Based Peptides with Antimicrobial Activity Against .

本文引用的文献

1
Characterization of plasmids carrying the blaOXA-24/40 carbapenemase gene and the genes encoding the AbkA/AbkB proteins of a toxin/antitoxin system.携带blaOXA - 24/40碳青霉烯酶基因以及编码毒素/抗毒素系统AbkA/AbkB蛋白的基因的质粒的特性分析。
J Antimicrob Chemother. 2014 Oct;69(10):2629-33. doi: 10.1093/jac/dku179. Epub 2014 May 30.
2
Measuring trends of outpatient antibiotic use in Europe: jointly modelling longitudinal data in defined daily doses and packages.衡量欧洲门诊抗生素使用趋势:对限定日剂量和包装中的纵向数据进行联合建模。
J Antimicrob Chemother. 2014 Jul;69(7):1981-6. doi: 10.1093/jac/dku063. Epub 2014 Mar 12.
3
对新型基于cathelicidin的肽进行体外和体内表征,这些肽对……具有抗菌活性
Antibiotics (Basel). 2025 Aug 19;14(8):838. doi: 10.3390/antibiotics14080838.
4
Protein functional domain analysis enhances genotype-phenotype associations in comparative genomic studies of .蛋白质功能域分析增强了[具体研究对象]比较基因组研究中的基因型-表型关联。 (原文结尾不完整,推测补充了研究领域相关内容,这里给出完整译文供参考)
Front Microbiol. 2025 Aug 6;16:1569118. doi: 10.3389/fmicb.2025.1569118. eCollection 2025.
5
Effect of photodynamic therapy with imipenem and gentamicin-derived carbon dots on the expression of quorum sensing and virulence genes in Pseudomonas aeruginosa.亚胺培南和庆大霉素衍生的碳点光动力疗法对铜绿假单胞菌群体感应和毒力基因表达的影响
BMC Microbiol. 2025 Jun 7;25(1):358. doi: 10.1186/s12866-025-04083-4.
6
Nanocarrier-based Drug Delivery Systems to Enhance Antimicrobial Photodynamic Therapy in Dental Applications: A Review.基于纳米载体的药物递送系统在牙科应用中增强抗菌光动力疗法的研究进展
AAPS PharmSciTech. 2025 Jun 3;26(5):160. doi: 10.1208/s12249-025-03155-y.
7
Antimicrobial Resistance in Diverse Ecological Niches-One Health Perspective and Food Safety.不同生态位中的抗菌药物耐药性——“同一个健康”视角与食品安全
Antibiotics (Basel). 2025 Apr 28;14(5):443. doi: 10.3390/antibiotics14050443.
8
High prevalence of low-concentration antimicrobial residues in commercial fish: A public health concern in Bangladesh.商业鱼类中低浓度抗菌药物残留的高流行率:孟加拉国的一个公共卫生问题。
PLoS One. 2025 May 27;20(5):e0324263. doi: 10.1371/journal.pone.0324263. eCollection 2025.
9
Antibiotic resistance patterns in uropathogens: insights from a Nepalese tertiary care setting.尿路病原体的抗生素耐药模式:来自尼泊尔一家三级医疗机构的见解。
Ther Adv Infect Dis. 2025 May 16;12:20499361251339383. doi: 10.1177/20499361251339383. eCollection 2025 Jan-Dec.
10
Phenotypic and genotypic characterization of carbapenemase-producing clinical isolates in Thi-Qar, Iraq.伊拉克济加尔省产碳青霉烯酶临床分离株的表型和基因型特征
Iran J Microbiol. 2025 Apr;17(2):268-277. doi: 10.18502/ijm.v17i2.18387.
Bacteriophages as potential treatment option for antibiotic resistant bacteria.
噬菌体作为治疗抗生素耐药菌的潜在选择。
Adv Exp Med Biol. 2014;807:97-110. doi: 10.1007/978-81-322-1777-0_7.
4
ESCMID guidelines for the management of the infection control measures to reduce transmission of multidrug-resistant Gram-negative bacteria in hospitalized patients.ESCMID 指南:管理感染控制措施以减少住院患者中多重耐药革兰氏阴性菌传播。
Clin Microbiol Infect. 2014 Jan;20 Suppl 1:1-55. doi: 10.1111/1469-0691.12427.
5
The role of antibiotic stewardship in limiting antibacterial resistance among hematology patients.抗生素管理在限制血液病患者抗菌药物耐药性方面的作用。
Haematologica. 2013 Dec;98(12):1821-5. doi: 10.3324/haematol.2013.091769.
6
Are patient views about antibiotics related to clinician perceptions, management and outcome? A multi-country study in outpatients with acute cough.患者对抗生素的看法与临床医生的认知、治疗及治疗结果有关吗?一项针对急性咳嗽门诊患者的多国研究。
PLoS One. 2013 Oct 23;8(10):e76691. doi: 10.1371/journal.pone.0076691. eCollection 2013.
7
Appropriate international measures for outpatient antibiotic prescribing and consumption: recommendations from a national data comparison of different measures.门诊抗生素处方与使用的适当国际措施:来自不同措施国家数据比较的建议
J Antimicrob Chemother. 2014 Feb;69(2):529-34. doi: 10.1093/jac/dkt385. Epub 2013 Oct 1.
8
Determinants of between-country differences in ambulatory antibiotic use and antibiotic resistance in Europe: a longitudinal observational study.欧洲国家间门诊抗生素使用和抗生素耐药性差异的决定因素:一项纵向观察研究。
J Antimicrob Chemother. 2014 Feb;69(2):535-47. doi: 10.1093/jac/dkt377. Epub 2013 Sep 29.
9
Patterns of initial antibiotic therapy for community-acquired pneumonia in U.S. hospitals, 2000 to 2009.2000 年至 2009 年美国医院获得性肺炎初始抗生素治疗模式。
Am J Med Sci. 2014 May;347(5):347-56. doi: 10.1097/MAJ.0b013e318294833f.
10
Escherichia coli sequence type 131 (ST131) subclone H30 as an emergent multidrug-resistant pathogen among US veterans.大肠杆菌序列型 131(ST131)子克隆 H30 作为一种新出现的美国退伍军人中多重耐药病原体。
Clin Infect Dis. 2013 Nov;57(9):1256-65. doi: 10.1093/cid/cit503. Epub 2013 Aug 6.