Boot C L, Luken J S, van den Burg P J M, de Kort W L A M, Koopman M M W, Vrielink H, van Schoor N M, den Heijer M, Lips P
Department of Internal Medicine/Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.
Department of Transfusion Medicine, Sanquin Blood Supply, Amsterdam, The Netherlands.
Vox Sang. 2015 Nov;109(4):410-3. doi: 10.1111/vox.12299. Epub 2015 May 29.
Apheresis donation using citrate causes acute decrease in serum calcium and increase in serum parathyroid hormone. Long-term consequences, such as decrease in bone mineral density (BMD), are not known. In this study, we compared the BMD of 20 postmenopausal apheresis donors (mean donation number 115 times in up to 15 years) with that of 20 whole blood donors (for 15 years or more) aged 55-70. BMD in the lumbar spine was not lower in apheresis donors than in blood donors (mean ± SD 1.00 ± 0.18 vs. 0.92 ± 0.12, P = 0.09). In the hip, BMD was not different between the groups.
使用柠檬酸盐进行单采捐献会导致血清钙急性降低和血清甲状旁腺激素升高。长期后果，如骨矿物质密度（BMD）降低，尚不清楚。在本研究中，我们比较了20名绝经后单采捐献者（平均捐献次数为115次，最长达15年）与20名年龄在55 - 70岁的全血捐献者（捐献15年或更长时间）的骨矿物质密度。单采捐献者腰椎的骨矿物质密度并不低于全血捐献者（平均值±标准差 1.00±0.18 对 0.92±0.12，P = 0.09）。在髋部，两组之间的骨矿物质密度没有差异。
