心肺适能改变老年人心肌功能与脑血流量之间的关系。
Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults.
作者信息
Johnson Nathan F, Gold Brian T, Bailey Alison L, Clasey Jody L, Hakun Jonathan G, White Matthew, Long Doug E, Powell David K
机构信息
Division of Physical Therapy, Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, Lexington, KY 40536, USA.
Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY 40536, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA.
出版信息
Neuroimage. 2016 May 1;131:126-32. doi: 10.1016/j.neuroimage.2015.05.063. Epub 2015 May 30.
A growing body of evidence indicates that cardiorespiratory fitness attenuates some age-related cerebral declines. However, little is known about the role that myocardial function plays in this relationship. Brain regions with high resting metabolic rates, such as the default mode network (DMN), may be especially vulnerable to age-related declines in myocardial functions affecting cerebral blood flow (CBF). This study explored the relationship between a measure of myocardial mechanics, global longitudinal strain (GLS), and CBF to the DMN. In addition, we explored how cardiorespiratory affects this relationship. Participants were 30 older adults between the ages of 59 and 69 (mean age=63.73years, SD=2.8). Results indicated that superior cardiorespiratory fitness and myocardial mechanics were positively associated with DMN CBF. Moreover, results of a mediation analysis revealed that the relationship between GLS and DMN CBF was accounted for by individual differences in fitness. Findings suggest that benefits of healthy heart function to brain function are modified by fitness.
越来越多的证据表明，心肺适能可减轻一些与年龄相关的大脑衰退。然而，关于心肌功能在这种关系中所起的作用，人们知之甚少。静息代谢率高的脑区，如默认模式网络（DMN），可能特别容易受到影响脑血流量（CBF）的心肌功能与年龄相关衰退的影响。本研究探讨了心肌力学指标——整体纵向应变（GLS）与DMN的CBF之间的关系。此外，我们还探讨了心肺适能如何影响这种关系。研究参与者为30名年龄在59岁至69岁之间的老年人（平均年龄=63.73岁，标准差=2.8）。结果表明，较高的心肺适能和心肌力学与DMN的CBF呈正相关。此外，中介分析结果显示，GLS与DMN的CBF之间的关系可由适能的个体差异来解释。研究结果表明，健康的心脏功能对脑功能的益处会因适能而有所改变。
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