5 年有氧运动对老年人认知功能的影响：第 100 代研究：一项随机对照试验。
Effects of 5 Years Aerobic Exercise on Cognition in Older Adults: The Generation 100 Study: A Randomized Controlled Trial.
机构信息
Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post Box 8905, 7491, Trondheim, Norway.
Norwegian National Advisory Unit for Functional MRI, Department of Radiology and Nuclear Medicine, St. Olav's University Hospital, Trondheim, Norway.
出版信息
Sports Med. 2022 Jul;52(7):1689-1699. doi: 10.1007/s40279-021-01608-5. Epub 2021 Dec 8.
OBJECTIVE
The objective of this study was to investigate whether a 5-year exercise intervention and change in peak oxygen uptake ([Formula: see text]) is associated with cognitive function in older adults.
METHODS
Nine hundred and forty-five participants (48% women, mean age at study end 78.2 ± 2.02 years) from the Generation 100 Study were randomized 2:1:1 to a control group, moderate-intensity continuous training or high-intensity interval training twice weekly for 5 years. Peak oxygen uptake was measured using ergospirometry at baseline and after 5 years. Global cognition and mild cognitive impairment (MCI) were assessed with the Montreal Cognitive Assessment scale (MoCA) after 5 years.
RESULTS
Compared to the control group, the combined moderate-intensity continuous training plus high-intensity interval training (ExComb) group did not have significantly different cognitive scores (beta value 0.26, 95% confidence interval [CI] - 0.17, 0.69) or odds of MCI (odds ratio 0.86, 95% CI 0.66, 1.13). Men in the ExComb group had 0.80 points higher MoCA (95% CI 0.21, 1.40) and 32% lower odds of MCI compared with male controls (95% CI 0.47, 0.99), with no such findings in women. In the total sample, each 1 metabolic equivalent of task increase in [Formula: see text] corresponded to 0.46 points higher MoCA (95% CI 0.25, 0.67) and 27% lower odds of MCI (95% CI 0.63, 0.85). Compared to [Formula: see text] stable, participants whose [Formula: see text] increased did not have significantly different cognitive scores (beta value 0.24, CI - 0.68, 1.15) or odds of MCI (odds ratio 0.70, 95% CI 0.36, 1.34), whereas participants whose [Formula: see text] decreased had 0.64 points lower MoCA (95% CI - 1.15, - 0.14) and 35% higher odds of MCI (95% CI 0.98, 1.87).
CONCLUSIONS
Overall, exercise was not significantly associated with cognition among older adults. However, maintaining or increasing [Formula: see text] appeared to benefit cognition.
CLINICAL TRIAL REGISTRATION
ClinicalTrials.gov NCT01666340.
目的
本研究旨在探讨 5 年的运动干预和峰值摄氧量（[Formula: see text]）的变化是否与老年人的认知功能有关。
方法
来自 Generation 100 研究的 945 名参与者（48%为女性，研究结束时的平均年龄为 78.2±2.02 岁）被随机分为对照组、中等强度持续训练组或高强度间歇训练组，每周进行 2 次、5 年的训练。使用心肺运动测试在基线和 5 年后测量峰值摄氧量。5 年后使用蒙特利尔认知评估量表（MoCA）评估整体认知和轻度认知障碍（MCI）。
结果
与对照组相比，中等强度持续训练加高强度间歇训练联合组（ExComb 组）的认知评分（β值 0.26，95%置信区间 [CI]−0.17，0.69）或 MCI 的比值比（OR）（0.86，95%CI 0.66，1.13）无显著差异。与男性对照组相比，ExComb 组的男性参与者 MoCA 高 0.80 分（95%CI 0.21，1.40），MCI 的比值比降低 32%（95%CI 0.47，0.99），而女性中未发现这种情况。在总样本中，每增加 1 代谢当量的任务量与 MoCA 高 0.46 分（95%CI 0.25，0.67）和 MCI 的比值比降低 27%（95%CI 0.63，0.85）相关。与 [Formula: see text]稳定相比，[Formula: see text]增加的参与者的认知评分（β值 0.24，CI−0.68，1.15）或 MCI 的比值比（OR）（0.70，95%CI 0.36，1.34）无显著差异，而 [Formula: see text]降低的参与者 MoCA 低 0.64 分（95%CI−1.15，−0.14），MCI 的比值比高 35%（95%CI 0.98，1.87）。
结论
总体而言，运动与老年人的认知功能没有显著关联。然而，保持或增加[Formula: see text]似乎有益于认知。
临床试验注册
ClinicalTrials.gov NCT01666340。
Zotero 插件