Naryshkin A G, Gurchin F A, Samoĭlov K A, Kirsanova G V, Vasilevskaia L S, Shvets Ia M
Vestn Khir Im I I Grek. 1989 Aug;144(8):50-3.
The spinal mechanism of the phantom pain origin is proved. The underlying factors are: segmentary spinal denervation hypersensitivity and attenuation of the descending inhibitory influence. The pathogenetic treatment of phantom pains is proposed by means of an associated treatment by GABA-ergic drug--Baclofen and alpha-2--adrenomimetic--Clofelin. Good effects of the proposed scheme of treatment confirm the correctness of the presented ideas of pathogenesis of phantom pains.
幻肢痛起源的脊髓机制已得到证实。潜在因素包括:节段性脊髓去神经超敏反应和下行抑制影响的减弱。通过联合使用γ-氨基丁酸能药物——巴氯芬和α-2肾上腺素能激动剂——可乐定提出了幻肢痛的病因治疗方法。所提出的治疗方案的良好效果证实了所阐述的幻肢痛发病机制观点的正确性。