Kukushkin M L, Reshetniak V K, Vorobeĭchik Ia M
Anesteziol Reanimatol. 1994 Jul-Aug(4):36-41.
Analgesic effects of morphine, clofelin, sirdalud, propranolol, and verapamil were studied in animals with the neurogenic painful syndrome induced by cutting the sciatic nerve and in patients with phantom painful syndrome after limb amputation. In animals with cut sciatic nerve morphine not only failed to prevent neurogenic pain, but was conducive to its increase. And, on the contrary, nontraditional analgesics clofelin, sirdalud, propranolol, and verapamil showed a high therapeutic efficacy both in experiments and in clinical trials. The results are discussed from the viewpoint of pathogenetic mechanisms of development of neurogenic painful syndromes.
在切断坐骨神经诱发神经源性疼痛综合征的动物以及肢体截肢后患有幻肢疼痛综合征的患者中，研究了吗啡、氯非林、西乐葆、普萘洛尔和维拉帕米的镇痛效果。在切断坐骨神经的动物中，吗啡不仅未能预防神经源性疼痛，反而促使其加剧。相反，非传统镇痛药氯非林、西乐葆、普萘洛尔和维拉帕米在实验和临床试验中均显示出较高的治疗效果。从神经源性疼痛综合征发生发展的发病机制角度对结果进行了讨论。
