Purswell B J, Dawe D L, Brown J
Department of Medical Microbiology, University of Georgia, Athens 30602.
Vet Immunol Immunopathol. 1989 Aug;22(1):29-37. doi: 10.1016/0165-2427(89)90161-x.
The effect of pregnancy and lactation on the cell-mediated immune response of first litter gilts was assessed using the response of circulating lymphocytes to in vitro mitogen stimulation and the cytotoxic activity of the circulating natural killer (NK) cells. Groups of gilts were sampled during the first, second and third trimester of gestation, weekly during lactation, at weaning and estrus following weaning of the piglets. No significant differences were found in the response of the cells from any of the groups to phytohemagglutinin A or concanavalin A stimulation. The natural killer cell activity, measured as cytotoxicity, decreased during gestation reaching a low point during the second and third week of lactation.
利用循环淋巴细胞对体外有丝分裂原刺激的反应以及循环自然杀伤（NK）细胞的细胞毒性活性，评估妊娠和哺乳对初产小母猪细胞介导免疫反应的影响。在妊娠的第一、第二和第三个月对小母猪组进行采样，在哺乳期间每周采样，在仔猪断奶时以及断奶后的发情期采样。未发现任何组的细胞对植物血凝素A或刀豆球蛋白A刺激的反应有显著差异。以细胞毒性衡量的自然杀伤细胞活性在妊娠期间下降，在哺乳的第二和第三周降至最低点。
