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英国儿童肥胖与常规药物使用之间的关联:对5至11岁儿童的纵向队列研究。

Association between childhood obesity and use of regular medications in the UK: longitudinal cohort study of children aged 5-11 years.

作者信息

Solmi Francesca, Morris Stephen

机构信息

Department of Applied Health Research, University College London, London, UK.

出版信息

BMJ Open. 2015 Jun 1;5(6):e007373. doi: 10.1136/bmjopen-2014-007373.

Abstract

OBJECTIVES

Increasing rates of childhood obesity have been suggested as a possible cause for the increasing prevalence of chronic conditions among adults and children. Few studies have examined whether obese children are more likely to use medications than normal weight children. We investigate this association in the UK.

DESIGN

A panel study with repeated observations at ages 5, 7 and 11.

SETTING

A general population sample drawn from the Millennium Cohort Study, a UK-based birth cohort.

PARTICIPANTS

A sample of 9667 children.

PRIMARY AND SECONDARY OUTCOME MEASURES

Our primary outcomes were crude and adjusted probabilities of taking any regular medications and the number of medications among overweight and obese children compared with normal weight children. Our secondary outcome was the distribution of medication use by therapeutic classification across body mass index (BMI) groups.

RESULTS

Obese children were more likely to use any medication (marginal effect (ME)=0.02, 95% CI 0.01 to 0.03) and to use more medications (ME=0.08, 95% CI 0.04 to 0.12) than normal weight children. Obese children used more medications for respiratory conditions than those of other BMI groups.

CONCLUSIONS

Obese children are more likely to use regular medications and have comorbid conditions, even at young ages. This suggests that the cost of prescriptions should be considered when evaluating the economic burden of childhood obesity and that preventative strategies to reduce childhood obesity could be cost-effective in the short as well as in the long term. While more research is needed, both clinicians and policymakers should be aware of these findings when planning prevention and treatment strategies.

摘要

目的

儿童肥胖率上升被认为可能是成人和儿童慢性病患病率增加的一个原因。很少有研究探讨肥胖儿童是否比正常体重儿童更有可能使用药物。我们在英国调查这种关联。

设计

一项在5岁、7岁和11岁时进行重复观察的队列研究。

背景

从英国出生队列千禧队列研究中抽取的一般人群样本。

参与者

9667名儿童的样本。

主要和次要结局指标

我们的主要结局是超重和肥胖儿童与正常体重儿童相比服用任何常规药物的粗略概率和调整概率以及药物数量。我们的次要结局是按治疗分类划分的药物使用在体重指数(BMI)组中的分布情况。

结果

与正常体重儿童相比,肥胖儿童更有可能使用任何药物(边际效应(ME)=0.02,95%置信区间0.01至0.03)且使用更多药物(ME=0.08,95%置信区间0.04至0.12)。肥胖儿童用于呼吸道疾病的药物比其他BMI组的儿童更多。

结论

肥胖儿童即使在年幼时也更有可能使用常规药物并患有合并症。这表明在评估儿童肥胖的经济负担时应考虑处方费用,并且减少儿童肥胖的预防策略在短期和长期都可能具有成本效益。虽然还需要更多研究,但临床医生和政策制定者在规划预防和治疗策略时都应了解这些发现。

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