Children's Mercy Kansas City, Kansas City, Missouri, USA.
University of Missouri, Kansas City School of Medicine, Kansas City, Missouri, USA.
Clin Transl Sci. 2021 Sep;14(5):2008-2016. doi: 10.1111/cts.13059. Epub 2021 May 31.
The liver is the primary organ responsible for clearing most drugs from the body and thus determines systemic drug concentrations over time. Drug clearance by the liver appears to be directly related to organ size. In children, organ size changes as children age and grow. Liver volume has been correlated with body surface area (BSA) in healthy children and adults and has been estimated by functions of BSA. However, these relationships were derived from "typical" populations and it is unknown whether they extend to estimations of liver volumes for population "outliers," such as children with overweight or obesity, who today represent one-third of the pediatric population. Using computerized tomography or magnetic resonance imaging, this study measured liver volumes in 99 children (2-21 years) with normal weight, overweight, or obesity and compared organ measurements with estimates calculated using an established liver volume equation. A previously developed equation relating BSA to liver volume adequately estimates liver volumes in children, regardless of weight status.
肝脏是主要负责清除体内大多数药物的器官，因此决定了药物在体内随时间的浓度。肝脏对药物的清除能力似乎与器官大小直接相关。在儿童中，随着年龄的增长和生长，器官大小会发生变化。在健康儿童和成人中，肝体积与体表面积（BSA）相关，并通过 BSA 的函数来估计。然而，这些关系是从“典型”人群中得出的，尚不清楚它们是否适用于超重或肥胖等“异常值”人群的肝体积估计，而超重或肥胖的儿童如今占儿科人群的三分之一。本研究使用计算机断层扫描或磁共振成像，测量了 99 名体重正常、超重或肥胖的儿童（2-21 岁）的肝体积，并将器官测量值与使用既定的肝体积方程计算的估计值进行了比较。一个先前开发的与 BSA 相关的肝体积方程可以充分估计儿童的肝体积，无论体重状况如何。
