Division of Women's Health, Women's Health Academic Centre, King's College London, St. Thomas' Hospital, London, United Kingdom.
Best Pract Res Clin Endocrinol Metab. 2012 Oct;26(5):627-39. doi: 10.1016/j.beem.2012.03.010. Epub 2012 Apr 30.
This review addresses the increasingly prolific literature from studies in man and animals suggesting that maternal obesity, a diet rich in calories or excess gestational weight gain may, through perturbation of the intrauterine environment, lead to lifelong risk of obesity and related disorders in the child. In addressing maternal- child obesity relationships it remains a challenge to distinguish the influence of the intrauterine environment from the contribution of shared genetic traits, and to adequately adjust for postnatal determinants of childhood obesity. Studies in genetically identical rodents convincingly show that maternal obesity, as well as elements of a hypercalorific diet can permanently influence offspring risk of obesity, and are these are supported by studies in larger mammals. Importantly, dissection of the mechanism in animals has led to description of novel interactive pathways between maternal environment and fetus which are amenable to investigation in humans.
这篇综述讨论了越来越多的人类和动物研究文献，这些文献表明，母体肥胖、高热量饮食或妊娠期间体重过度增加，可能通过扰乱宫内环境，导致儿童终身肥胖和相关疾病的风险增加。在探讨母婴肥胖关系时，仍然存在一个挑战，即要区分宫内环境的影响和共同遗传特征的贡献，并充分调整儿童肥胖的后天决定因素。在遗传上完全相同的啮齿动物研究中，令人信服地表明，母体肥胖以及高热量饮食的元素都可以永久影响后代肥胖的风险，而较大的哺乳动物研究也支持这一观点。重要的是，动物研究中的剖析揭示了母体环境和胎儿之间新的相互作用途径，这些途径可以在人类中进行研究。
