Ablajan Keyume, Panetti Grace B, Yang Xiaodong, Kim Byeong-Seon, Walsh Patrick J
Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, PR China.
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Adv Synth Catal. 2017 Jun 6;359(11):1927-1932. doi: 10.1002/adsc.201700380. Epub 2017 May 23.
The direct arylation of weakly acidic sp-hybridized C-H bonds via deprotonated cross-coupling processes (DCCP) is a challenge. Herein, a Pd(NIXANTPHOS)-based catalyst for the mono arylation of 4-pyridylmethyl 2-aryl ethers to generate diarylated 4-pyridyl methyl ethers is introduced. Furthermore, under similar conditions, the diarylation of 4-pyridylmethyl ethers with aryl bromides has been developed. These methods enable the synthesis of new pyridine derivatives, which are common in medicinally active compounds and in application in materials science.
通过去质子化交叉偶联过程（DCCP）对弱酸性sp杂化C-H键进行直接芳基化是一项挑战。本文介绍了一种基于Pd（NIXANTPHOS）的催化剂，用于4-吡啶基甲基2-芳基醚的单芳基化反应，以生成二芳基化的4-吡啶基甲基醚。此外，在类似条件下，已开发出4-吡啶基甲基醚与芳基溴的二芳基化反应。这些方法能够合成新的吡啶衍生物，这些衍生物在药用活性化合物和材料科学应用中很常见。
