Pd(0)催化的 4-甲基喹唑啉的苄基芳基化-氧化反应：在空气条件下通过 sp3 C-H 活化。
Pd(0)-catalyzed benzylic arylation-oxidation of 4-methylquinazolines via sp3 C-H activation under air conditions.
机构信息
State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
出版信息
Org Biomol Chem. 2013 Oct 7;11(37):6246-9. doi: 10.1039/c3ob41488d.
PMID:23959586
Abstract
An efficient and selective Pd(0)-catalyzed sp(3) C-H bond arylation-oxidation of 4-methylquinazolines is reported. The method enables the introduction of arylketone at the benzylic position of 4-methylquinazolines without the use of an additional directing group, and atmospheric oxygen is used as the sole oxidant.
摘要
报道了一种高效、选择性的 Pd(0)催化 sp(3) C-H 键芳基化-氧化 4-甲基喹唑啉的方法。该方法能够在 4-甲基喹唑啉的苄位引入芳基酮，而无需使用额外的导向基团，并且可以使用大气氧作为唯一的氧化剂。
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