State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
Org Biomol Chem. 2013 Oct 7;11(37):6246-9. doi: 10.1039/c3ob41488d.
An efficient and selective Pd(0)-catalyzed sp(3) C-H bond arylation-oxidation of 4-methylquinazolines is reported. The method enables the introduction of arylketone at the benzylic position of 4-methylquinazolines without the use of an additional directing group, and atmospheric oxygen is used as the sole oxidant.
报道了一种高效、选择性的 Pd(0)催化 sp(3) C-H 键芳基化-氧化 4-甲基喹唑啉的方法。该方法能够在 4-甲基喹唑啉的苄位引入芳基酮，而无需使用额外的导向基团，并且可以使用大气氧作为唯一的氧化剂。
