Castillo-Pelayo Tania, Babinszky Sindy, LeBlanc Jodi, Watson Peter H
1Tumour Tissue Repository, Trev and Joyce Deeley Research Centre, BC Cancer Agency, Victoria, British Columbia, Canada.
2Office of Biobank Education and Research, Department of Pathology and Laboratory Medicine, BC Cancer Agency and UBC, Vancouver, British Columbia, Canada.
Biopreserv Biobank. 2015 Jun;13(3):172-7. doi: 10.1089/bio.2014.0061.
Establishing the importance of biobanking in cancer research is important for research funders and for planning health research infrastructure. This study delineates the importance of biobanking to the cancer research landscape in Canada and relative to other forms of health research infrastructure.
The Cancer Research Society (CRS) is a Canadian organization with a broad mission and national portfolio that funds studies across the spectrum of cancer research. We selected all 35 investigators who received CRS grants in the 2010/11 competition and then analyzed their publications from 2010 to 2014. Articles were categorized by overall research area, acknowledged source of funding, specific scientific focus, and the presence of any data that involved an 'indicator' (human biospecimens, cell lines, animal models, advanced microscopy, flow cell sorters, and next generation sequencing) of dependence on different kinds of health research infrastructures. Publications involving biobanking and utilizing biospecimens were further classified by biospecimen provenance and type of biospecimen used.
These investigators generated 502 (from a total of 749) papers that were related to the field of cancer research. Amongst 445 papers that contained primary data, we found no significant differences between CRS funded and 'other funded' papers in terms of biospecimen use, which occurred in 38% of articles. Overall biospecimens were mostly obtained directly from patients (17%), or indirectly from biorepositories (31%) and hospitals (46%). The proportions of studies using other tools was as follows: 54% cell lines, 32% animal models, 14% advanced microscopy, 14% flow sorters, and 8% next generation sequencing. The spectrum of research was very similar to the overall profile of cancer research in Canada in 2010.
This study suggests that biorepositories that coordinate the activity of biobanking rank amongst the most important of established health research infrastructures as contributors to research publications.
确立生物样本库在癌症研究中的重要性，对研究资助者和规划卫生研究基础设施而言至关重要。本研究阐述了生物样本库对加拿大癌症研究格局的重要性，以及相对于其他形式的卫生研究基础设施的重要性。
癌症研究协会（CRS）是一个加拿大组织，其使命广泛，拥有全国性项目组合，为癌症研究各领域的研究提供资助。我们选取了在2010/11年度竞赛中获得CRS资助的所有35位研究人员，然后分析了他们在2010年至2014年期间发表的论文。文章按总体研究领域、认可的资金来源、具体科学重点以及是否存在涉及依赖不同类型卫生研究基础设施的“指标”（人类生物样本、细胞系、动物模型、先进显微镜、流式细胞分选仪和下一代测序）的任何数据进行分类。涉及生物样本库并使用生物样本的出版物，进一步按生物样本来源和所用生物样本类型进行分类。
这些研究人员发表了502篇（总共749篇）与癌症研究领域相关的论文。在445篇包含原始数据的论文中，我们发现CRS资助的论文和“其他资助”的论文在生物样本使用方面没有显著差异，38%的文章使用了生物样本。总体而言，生物样本大多直接从患者处获得（17%），或间接从生物样本库（31%）和医院（46%）获得。使用其他工具的研究比例如下：细胞系54%，动物模型32%，先进显微镜14%，流式分选仪14%，下一代测序8%。研究范围与2010年加拿大癌症研究的总体概况非常相似。
本研究表明，协调生物样本库活动的生物样本库是已建立的卫生研究基础设施中，对研究出版物贡献最大的设施之一。
