Natural Medicine Center, KIST Gangneung Institute, Gangneung, Gangwon 210-340, Republic of Korea.
College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 534-729, Republic of Korea.
Int J Mol Med. 2015 Aug;36(2):527-33. doi: 10.3892/ijmm.2015.2227. Epub 2015 May 29.
In the present study, the anti-diabetic effects of amorphastilbol (APH) from Amorpha fruticosa (AF) were evaluated in high-fat-diet (HFD) mice. HFD-induced blood glucose and insulin levels are significantly reduced in AF extract or APH treatment groups. HFD-induced weight gain was reduced by AF treatment, which is accompanied by reduction of fat mass and adipocyte size and number in white adipose tissues. Furthermore, total cholesterol and low-density lipoprotein-cholesterol levels are decreased in AF- or APH-treated mice. In addition, AF and APH are able to improve insulin sensitivity through inhibition of protein tyrosine phosphatase 1B, a negative regulator of the insulin-signaling pathway. Taken together, the data suggest that AF has beneficial effects on glucose and lipid metabolism and its pharmacological effects are driven, in part, by its active component, APH. Therefore, AF and APH can be used as potential therapeutic agents against type 2 diabetes and associated metabolic disorders, including obesity, by enhancing glucose and lipid metabolism.
在本研究中，评估了紫穗槐二萜醇（APH）对高脂肪饮食（HFD）诱导的糖尿病模型小鼠的抗糖尿病作用。紫穗槐提取物或 APH 处理组可显著降低 HFD 诱导的血糖和胰岛素水平。AF 处理可降低 HFD 诱导的体重增加，同时减少白色脂肪组织中的脂肪质量和脂肪细胞大小和数量。此外，总胆固醇和低密度脂蛋白胆固醇水平在 AF 或 APH 处理的小鼠中降低。此外，AF 和 APH 可通过抑制胰岛素信号通路的负调节剂蛋白酪氨酸磷酸酶 1B 来改善胰岛素敏感性。综上所述，这些数据表明，AF 对葡萄糖和脂质代谢有有益的影响，其药理学作用部分是由其活性成分 APH 驱动的。因此，AF 和 APH 可通过增强葡萄糖和脂质代谢，作为治疗 2 型糖尿病和相关代谢紊乱（包括肥胖症）的潜在治疗剂。
