Khonicheva N M, Lushchekina E A, Kurbatyova M B, Guliaeva N V, Obidin A B
Zh Vyssh Nerv Deiat Im I P Pavlova. 1989 Sep-Oct;39(5):869-76.
In 20 white rats bilateral coagulation of the amygdalar complex was produced; on the fifth day to one half of them transplantation was performed by introducing stereotaxically on the left side 0.2-0.5 mm3 of the brain embryonal tissue from the corresponding area of the amygdala of 20-days embryo; in control saline was administered. After two months the rats were sacrificed to determine the activity of antiradical defense by superoxide dismutase (SOD) and the level of lipids peroxide oxidation (LPO) in the cerebral cortex. The transplantation decreased LPO even more and increased SOD as compared to amygdalectomy, e. i. caused still greater deviations from the norm (in this meaning--paradoxal effect), what apparently corresponds to intensification of adaptative-compensatory processes caused by amygdalectomy. The transplantation did not reverse the rats behaviour to the initial one and did not eliminate memory defect in the test of conditioned reaction of passive avoidance (like pyrazetam); it had different direction influence on "drinking under current" in conflict situation, only in particular cases approaching it to the norm.
对20只白鼠进行杏仁核复合体双侧凝固；在第5天，对其中一半白鼠进行移植，通过立体定位在左侧引入来自20天胚胎杏仁核相应区域的0.2 - 0.5立方毫米脑胚胎组织；对照组注射生理盐水。两个月后处死大鼠，以通过超氧化物歧化酶（SOD）测定抗自由基防御活性以及大脑皮质中脂质过氧化（LPO）水平。与杏仁核切除术相比，移植使LPO进一步降低且SOD升高，即导致与正常情况的偏差更大（从这个意义上讲——矛盾效应），这显然对应于杏仁核切除术引起的适应性 - 代偿过程的强化。移植并未使大鼠行为恢复到初始状态，也未消除被动回避条件反应测试中的记忆缺陷（如吡拉西坦）；在冲突情境中，它对“电流下饮水”有不同方向的影响，仅在特定情况下使其接近正常。
