Derrick Chase D, Shridharani Sachin M, Broyles Justin M
Dr Derrick is a Resident, Division of Plastic Surgery, Department of Surgery, University of Missouri-Columbia in Columbia, Missouri. Dr Shridharani is a plastic surgeon in private practice in New York, New York. Dr Broyles is a Resident, Department of Plastic Surgery, Johns Hopkins University School of Medicine in Baltimore, Maryland.
Aesthet Surg J. 2015 Sep;35(7):830-6. doi: 10.1093/asj/sjv039. Epub 2015 Jun 2.
In the past decade, the practice of body contouring using cryolipolysis has increased tremendously. While numerous anecdotal reports extol the efficacy of this product, the majority of these studies are small, retrospective case-series that lack control groups.
The authors aim to systematically review available literature to better illustrate the efficacy and safety of this new procedure.
A systematic literature review performed using MEDLINE, Embase, PubMed, and Cochrane databases identified all published studies evaluating cryolipolysis for body contouring.
A total of 34 articles up to February 2015 were identified. Nineteen articles matched the selection criteria and were included in the analysis. Sixteen were evaluated in the final analysis. A total of 1445 patients had reportable data for analysis of the safety profile. Twelve patients (0.82%) reported complications with the most common being diminished sensation lasting greater than 4 weeks. An aggregate total of 295 patients had objective data for evaluation of tissue reduction. The mean time from procedure to objective outcome evaluation was 3.83 months. The mean reduction of subcutaneous tissue was 19.55% with respect to a designated control site.
Selective cryolipolysis appears, at short-term follow-up, to reliably decrease subcutaneous tissue deposits. Reported complications are uncommon and appear to resolve without intervention. Future studies should aim to optimize patient selection and treatment characteristics while obtaining long-term follow-up data.
在过去十年中，使用冷冻溶脂术进行身体塑形的做法急剧增加。虽然众多轶事报道称赞了该产品的功效，但这些研究大多是小型回顾性病例系列，缺乏对照组。
作者旨在系统回顾现有文献，以更好地说明这种新手术的疗效和安全性。
使用MEDLINE、Embase、PubMed和Cochrane数据库进行系统文献回顾，确定了所有评估冷冻溶脂术用于身体塑形的已发表研究。
截至2015年2月，共识别出34篇文章。19篇文章符合选择标准并纳入分析。最终分析中评估了16篇。共有1445例患者有可报告数据用于安全性分析。12例患者（0.82%）报告了并发症，最常见的是感觉减退持续超过4周。共有295例患者有客观数据用于评估组织减少情况。从手术到客观结果评估的平均时间为3.83个月。相对于指定对照部位，皮下组织的平均减少量为19.55%。
在短期随访中，选择性冷冻溶脂术似乎能可靠地减少皮下组织堆积。报告的并发症不常见，且似乎无需干预即可解决。未来的研究应旨在优化患者选择和治疗特征，同时获取长期随访数据。
