超重和肥胖患者对减肥计划的血脂反应与性别和年龄有关。

Lipid profile response to weight loss program in overweight and obese patient is related with gender and age.

作者信息

Romero-Moraleda Blanca, Peinado Lozano Ana Belén, Morencos Martínez Esther, López-Plaza Bricia, Gómez Candela Carmen, Calderón Montero Francisco Javier

机构信息

Healthy Sciences Faculty. Camilo José Cela University. (Villanueva de la Cañada), Madrid. EFISAF Research Group. Technical University of Madrid, Spain..

Department of Health and Human Performance. School of Physical Activity and Sport Sciences. Technical University of Madrid, Madrid. EFISAF Research Group. Technical University of Madrid, Spain..

出版信息

Nutr Hosp. 2015 Jun 1;31(6):2455-64. doi: 10.3305/nh.2015.31.6.8926.

DOI:10.3305/nh.2015.31.6.8926

PMID:26040352

Abstract

INTRODUCTION

The risk of developing cardiovascular disease (CVD) increases with age, however CVD is markedly higher in men than in no-menopausal women. There are few interventions where compare the different effects to lose weight on lipid profile between men and women.

OBJECTIVE

The aim of this study was to compare the response on the lipid profile by gender after a weight loss program, and determine whether there are differences by age group.

METHODS

One hundred eighty (96 women and 84 men) overweight and obese participants (BMI 25-34.9 kg/m2) aged 18-50 years were randomised into treatment groups. The intervention period was 22 weeks (in all cases 3 times/wk of training for 22 weeks and 2 weeks for pre and post evaluation). All subjects followed a hypocaloric diet (25-30% less energy intake). Energy intake, body composition) and blood lipid profile were recorded at baseline and after of treatment.

RESULTS

The response of HDL varied between men and women (p = 0.001). While in women it decreased (HDL: -2.94%, p = 0.02), HDL was elevated in men (HDL: 5% p = 0.02). After intervention men achieved decrease significantly LDL values a 6.65% more than women (p = 0.01). For TG concentrations there were significant differences between men and women in baseline however, only men had a significant chance in post-training measured (p = 0.001). TC showed significant differences between men and women in baseline (p = 0.013). After intervention, men and women showed a significant decreased to TC (p = 0.01).

CONCLUSION

Men achieve a positive greater change on lipid profile than women. In addition, the favorable lipid profile response decreases with increasing age.

摘要

引言

心血管疾病（CVD）的发病风险随年龄增长而增加，然而男性患CVD的风险明显高于未绝经女性。很少有干预措施比较男女减肥对血脂谱的不同影响。

目的

本研究的目的是比较减肥计划后男女对血脂谱的反应，并确定不同年龄组之间是否存在差异。

方法

180名（96名女性和84名男性）年龄在18至50岁之间的超重和肥胖参与者（BMI 25-34.9 kg/m²）被随机分为治疗组。干预期为22周（在所有情况下，每周训练3次，共22周，前后评估各2周）。所有受试者均遵循低热量饮食（能量摄入减少25-30%）。在基线和治疗后记录能量摄入、身体成分和血脂谱。

结果

男女高密度脂蛋白（HDL）的反应有所不同（p = 0.001）。女性HDL降低（HDL：-2.94%，p = 0.02）而男性HDL升高（HDL：5% p = 0.02）。干预后男性低密度脂蛋白（LDL）值的下降幅度比女性多6.65%（p = 0.01）。对于甘油三酯（TG）浓度，男女在基线时有显著差异，然而，只有男性在训练后测量时有显著变化（p = 0.001）。总胆固醇（TC）在基线时男女之间存在显著差异（p = 0.013）。干预后，男性和女性的TC均显著下降（p = 0.01）。