隔日禁食的减肥效果是否因性别和绝经状态而异？
Does the weight loss efficacy of alternate day fasting differ according to sex and menopausal status?
机构信息
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, USA.
出版信息
Nutr Metab Cardiovasc Dis. 2021 Feb 8;31(2):641-649. doi: 10.1016/j.numecd.2020.10.018. Epub 2020 Oct 31.
BACKGROUND AND AIMS
This study examined if the weight loss and metabolic benefits of alternate day fasting (ADF) varies according to sex and menopausal status in adults with obesity.
METHODS AND RESULTS
This secondary analysis pooled the data of men and women (n = 75) who participated in three 12-week ADF studies (500 kcal fast day; alternated with an ad libitum intake feast day). Body weight decreased in premenopausal women (-4.6 ± 3.2%), postmenopausal women (-6.5 ± 3.2%) and men (-6.2 ± 4.4%) (main effect of time, P < 0.001), with no difference between groups (no group × time interaction). Energy intake on fast days was higher than prescribed in all groups (∼400-500 excess kcal consumed), with no differences between groups. Fat mass, lean mass, fasting insulin, and insulin resistance, and blood pressure decreased similarly in all groups (main effect of time, P < 0.05 for all comparisons). LDL cholesterol decreased more in postmenopausal versus premenopausal women (group × time interaction, P = 0.01). Fasting glucose, HDL cholesterol, and triglycerides remained unchanged in all groups.
CONCLUSION
These findings suggest that the weight loss and metabolic benefits of ADF do not generally vary according to sex or menopausal status in adults with obesity.
TRIAL REGISTRATION
Clinicaltrials.gov, NCT00960505; NCT03528317.
背景与目的
本研究旨在探讨在肥胖成年人中，隔日禁食（ADF）的减肥和代谢益处是否因性别和绝经状态而异。
方法和结果
本二次分析汇总了参加三项为期 12 周的 ADF 研究（禁食日 500 千卡；与随意摄入的盛宴日交替）的男性和女性（n=75）的数据。绝经前女性（-4.6±3.2%）、绝经后女性（-6.5±3.2%）和男性（-6.2±4.4%）的体重均下降（主要时间效应，P<0.001），但组间无差异（无组×时间交互作用）。所有组的禁食日能量摄入均高于规定（约多摄入 400-500 千卡），且组间无差异。所有组的体脂量、瘦体重、空腹胰岛素和胰岛素抵抗以及血压均相似下降（所有比较的主要时间效应，P<0.05）。与绝经前女性相比，绝经后女性的 LDL 胆固醇下降更多（组×时间交互作用，P=0.01）。所有组的空腹血糖、HDL 胆固醇和甘油三酯均保持不变。
结论
这些发现表明，在肥胖成年人中，ADF 的减肥和代谢益处通常不受性别或绝经状态的影响。
试验注册
Clinicaltrials.gov，NCT00960505；NCT03528317。
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