微小RNA-124在中枢神经系统疾病中的最新作用：综述
An updated role of microRNA-124 in central nervous system disorders: a review.
作者信息
Sun Yang, Luo Zhu-Min, Guo Xiu-Ming, Su Ding-Feng, Liu Xia
机构信息
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai China.
出版信息
Front Cell Neurosci. 2015 May 20;9:193. doi: 10.3389/fncel.2015.00193. eCollection 2015.
Abstract
MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases.
摘要
微小RNA - 124（miR - 124）是大脑中含量最为丰富的微小RNA。miR - 124的生物合成在各种细胞和组织类型中呈现出特定的时空分布模式，并影响中枢神经系统（CNS）的广泛生物学功能。最近，miR - 124失调与中枢神经系统疾病（如神经退行性变、中枢神经系统应激、神经免疫疾病、中风和脑肿瘤）之间的联系已变得明显。在此，我们概述了miR - 124在中枢神经系统中的特定分子功能，并对miR - 124在治疗人类中枢神经系统疾病方面的治疗潜力提供了深刻见解。
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