Zhao Jiuhan, He Zhenwei, Wang Jialu
Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, China.
Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Front Cell Neurosci. 2021 Nov 2;15:771898. doi: 10.3389/fncel.2021.771898. eCollection 2021.
Neurological disorders are mainly characterized by progressive neuron loss and neurological deterioration, which cause human disability and death. However, many types of neurological disorders have similar pathological mechanisms, including the neuroinflammatory response. Various microRNAs (miRs), such as miR-21, miR-124, miR-146a, and miR-132 were recently shown to affect a broad spectrum of biological functions in the central nervous system (CNS). Microglia are innate immune cells with important roles in the physiological and pathological activities of the CNS. Recently, abnormal expression of miR-124 was shown to be associated with the occurrence and development of various diseases in CNS via regulating microglia function. In addition, miR-124 is a promising biomarker and therapeutic target. Studies on the role of miR-124 in regulating microglia function involved in pathogenesis of neurological disorders at different stages will provide new ideas for the use of miR-124 as a therapeutic target for different CNS diseases.
神经疾病主要以进行性神经元丧失和神经功能恶化为特征，这会导致人类残疾和死亡。然而，许多类型的神经疾病具有相似的病理机制，包括神经炎症反应。最近研究表明，多种微小RNA（miR），如miR-21、miR-124、miR-146a和miR-132，会影响中枢神经系统（CNS）的广泛生物学功能。小胶质细胞是先天性免疫细胞，在中枢神经系统的生理和病理活动中发挥重要作用。最近研究表明，miR-124的异常表达通过调节小胶质细胞功能与中枢神经系统各种疾病的发生和发展相关。此外，miR-124是一种有前景的生物标志物和治疗靶点。研究miR-124在不同阶段调节参与神经疾病发病机制的小胶质细胞功能中的作用，将为把miR-124用作不同中枢神经系统疾病的治疗靶点提供新思路。
