Smadja A, Hervé de Sigalony J P, Orcel L
Arch Anat Cytol Pathol. 1989;37(5-6):201-7.
We report the results of a histologic study of the differentiating ovary carried out in human embryos and fetuses. Up to the sixth week, the anlage of the gonad is formed by the proliferation of cells originating from the coelomic mesothelium; this proliferation starts with the migration of the primordial germ cells. Between the sixth and the tenth weeks, the primary mesenchyma invades the epithelial mass and divides it into "cords"; by division, the germ cells contained within the mass become ovocytes. At the tenth week, the gonad takes shape and is separated from the mesonephros. At the twelfth week, the gonad is formed of two zones; an outer zone formed of epithelial clusters arranged in rosettes around the ovocytes; and an inner, mesenchymal, zone that becomes the medulla and separates the outer epithelial zone from the remnants of the mesonephros. At the sixteenth week, the gonad becomes the ovary that contains millions of primordial follicles; each follicle consists of an ovocyte surrounded by a ring of granulosa cells originating from the coelomic epithelium; the follicles are separated from each other by mesenchymal cells that form the cortical stroma. The remnants of the mesonephros are clearly separated from the ovary by the medulla.(ABSTRACT TRUNCATED AT 250 WORDS)
我们报告了一项对人类胚胎和胎儿分化中的卵巢进行组织学研究的结果。在第六周之前，性腺原基由源自体腔间皮的细胞增殖形成；这种增殖始于原始生殖细胞的迁移。在第六至第十周之间，初级间充质侵入上皮团块并将其分成“索状结构”；通过分裂，团块内的生殖细胞变成卵母细胞。在第十周时，性腺成形并与中肾分离。在第十二周时，性腺由两个区域组成；一个外部区域由围绕卵母细胞呈玫瑰花结排列的上皮细胞簇构成；以及一个内部的间充质区域，该区域成为髓质，并将外部上皮区域与中肾残余部分分隔开。在第十六周时，性腺变成卵巢，其中包含数百万个原始卵泡；每个卵泡由一个卵母细胞和一层源自体腔上皮的颗粒细胞环绕而成；卵泡由形成皮质基质的间充质细胞彼此分隔开。中肾残余部分通过髓质与卵巢明显分开。（摘要截选至250字）
