Kurilo L F
Arkh Anat Gistol Embriol. 1980 Jul;79(7):73-9.
In 97 embryos and fetuses (6--40-week-old) quantitative analysis of the ovarian growth, dynamic of development of sex cell population and their mitotic activity have been morphologically studied during prenatal development. It has been demonstrated that sex differentiation of the ovaries takes place at the beginning of the 6th week. Connective tissue cords of the cortical substance stroma have been stated to appear in 6-week-old embryos, develop centrifugally and reach covering epithelium by the 19th--20th week of embryogenesis. Connective tissue elements of the ovarian tunica albuginea appear on the 27th week and by the 40th week the ovarian tunica albuginea is distinctly seen. Formation of the medulary substance germ beginning on the 6th--7th week has been observed when the gonade is separated from mesonephros and mesovarium is formed. Maximal mitotic activity in the oogonium occurs on the 11th -- 26th weeks. During the same period (the 11th -- 17th weeks) the relative amount of germ cells reaches its maximum, and most of oocytes achieve the meiotic prophase. After the 17th week of the intrauterine development, an intensive proliferation of the ovarian somatic elements and folliculogenesis are observed.
对97个胚胎和胎儿（6至40周龄）在产前发育期间的卵巢生长、性细胞群体发育动态及其有丝分裂活性进行了形态学定量分析。结果表明，卵巢的性别分化在第6周开始。皮质物质基质的结缔组织索在6周龄胚胎中出现，离心发育并在胚胎发生的第19至20周到达覆盖上皮。卵巢白膜的结缔组织成分在第27周出现，到第40周时卵巢白膜清晰可见。当性腺与中肾分离并形成卵巢系膜时，观察到从第6至7周开始髓质物质胚芽的形成。卵原细胞的最大有丝分裂活性出现在第11至26周。在同一时期（第11至17周），生殖细胞的相对数量达到最大值，并且大多数卵母细胞进入减数分裂前期。在子宫内发育的第17周后，观察到卵巢体细胞成分的强烈增殖和卵泡发生。
