Hutcheson Jack
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.
Cytokine. 2015 Oct;75(2):272-9. doi: 10.1016/j.cyto.2015.04.004. Epub 2015 Jun 1.
Over the past few decades, our understanding of the role of adipose tissue has changed dramatically. Far from simply being a site of energy storage or a modulator of the endocrine system, adipose tissue has emerged as an important regulator of multiple important processes including inflammation. Adipokines are a diverse family of soluble mediators with a range of specific actions on the immune response. Autoimmune diseases are perpetuated by chronic inflammatory responses but the exact etiology of these diseases remains elusive. While researchers continue to investigate these causes, millions of people continue to suffer from chronic diseases. To this end, an increased interest has developed in the connection between adipose tissue-secreted proteins that influence inflammation and the onset and perpetuation of autoimmunity. This review will focus on recent advances in adipokine research with specific attention on a subset of adipokines that have been associated with autoimmune diseases.
在过去几十年里，我们对脂肪组织作用的理解发生了巨大变化。脂肪组织远非仅仅是能量储存的场所或内分泌系统的调节者，它已成为包括炎症在内的多个重要过程的重要调节因子。脂肪因子是一类多样的可溶性介质，对免疫反应有一系列特定作用。自身免疫性疾病由慢性炎症反应持续存在，但这些疾病的确切病因仍然难以捉摸。在研究人员继续探究这些病因的同时，数百万人仍在遭受慢性病的折磨。为此，人们对影响炎症的脂肪组织分泌蛋白与自身免疫性疾病的发生和持续存在之间的联系越来越感兴趣。本综述将聚焦于脂肪因子研究的最新进展，特别关注与自身免疫性疾病相关的一部分脂肪因子。
