Romero-Sánchez Consuelo, De Avila Juliette, Ramos-Casallas Alejandro, Chila-Moreno Lorena, Delgadillo Nathaly Andrea, Chalem-Choueka Philippe, Pacheco-Tena César, Bello-Gualtero Juan Manuel, Bautista-Molano Wilson
Cellular and Molecular Immunology Group (INMUBO), School of Dentistry, Universidad El Bosque, Av. Carrera 9 No. 131A-02, Bogotá 110121, Colombia.
Clinical Immunology Group, Rheumatology and Immunology Department, Hospital Militar Central, Transversal 3 # 49-00, Bogotá 110231, Colombia.
Diagnostics (Basel). 2023 Mar 16;13(6):1126. doi: 10.3390/diagnostics13061126.
Adipokines are associated with the pathogenesis of rheumatoid arthritis (RA) and are potential biomarkers of disease activity, periodontitis, and obesity. The aim of this was to establish the association between adipokine profile, RA disease activity, body mass index, and periodontal infection. This study evaluated 51 patients with early-RA and 51 controls including serum rheumatological markers, adipokine levels, detection of and serum anti- antibodies, clinical and periodontal measurements. Statistical analyses were run with SPSS V26, with a logistic regression model to confirm associations. The results show high levels of leptin were more frequent in patients ( = 0.001) who simultaneously showed a higher frequency of ( = 0.004). Patients with concomitant presence of , high clinical activity score, and overweight were correlated with high levels of leptin (OR, 7.20; 95% CI, 2.68-19.33; = 0.0001) and adipsin (OR, 2.69; 95% CI, 1.00-7.28; = 0.005). The conclusion is that high levels of leptin and adipsin are associated with greater clinical activity in early-RA patients with overweight and periodontal infection, whereby overweight and may enhance RA activity. This may represent a pathological mechanism between these conditions, where adipokines seem to have a key role.
脂肪因子与类风湿关节炎（RA）的发病机制相关，是疾病活动、牙周炎和肥胖的潜在生物标志物。本研究的目的是确定脂肪因子谱、RA疾病活动、体重指数和牙周感染之间的关联。本研究评估了51例早期RA患者和51例对照，包括血清风湿学标志物、脂肪因子水平、检测和血清抗抗体、临床和牙周测量。使用SPSS V26进行统计分析，采用逻辑回归模型确认关联。结果显示，瘦素水平高在同时显示频率较高的患者中更常见（=0.001）（=0.004）。同时存在、高临床活动评分和超重的患者与瘦素（OR，7.20；95%CI，2.68 - 19.33；=0.0001）和脂肪酶（OR，2.69；95%CI，1.00 - 7.28；=0.005）水平高相关。结论是，在超重和牙周感染的早期RA患者中，高瘦素和脂肪酶水平与更高的临床活动相关，超重和可能会增强RA活动。这可能代表了这些情况之间的一种病理机制，其中脂肪因子似乎起关键作用。
