Joya Xavier, Pacifici Roberta, Salat-Batlle Judith, García-Algar Oscar, Pichini Simona
1Unitat de Recerca Infància i Entorn (URIE), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
2Red de Salud Materno-Infantil y del Desarrollo (SAMID), Programa RETICS, Instituto Carlos III, Madrid, Spain.
Bioanalysis. 2015;7(10):1273-97. doi: 10.4155/bio.15.60.
Perinatal exposure to one or more drugs of abuse can affect the neonate temporarily or permanently. In addition to meconium, the evaluation of perinatal exposure to drugs of abuse has been achieved by testing biological matrices coming from the newborn (neonatal hair) and from the pregnant or nursing mother (maternal hair and breast milk). These matrices have the advantage of noninvasive collection and account for a sizable time window of active and passive exposure. Sensitive and specific analytical methods are required to determine minute amounts of drugs of abuse and metabolites in these matrices. The present manuscript reviews the newest analytical methods developed to detect drugs of abuse as well as ethanol biomarkers in maternal and neonatal hair and breast milk.
围产期接触一种或多种滥用药物会对新生儿产生暂时或永久性影响。除胎粪外，还可通过检测新生儿（新生儿毛发）以及孕妇或哺乳期母亲（母亲毛发和母乳）的生物样本，来评估围产期对滥用药物的接触情况。这些样本具有非侵入性采集的优势，且涵盖了主动和被动接触的相当长的时间窗口。需要灵敏且特异的分析方法来测定这些样本中痕量的滥用药物及其代谢物。本文综述了为检测母亲和新生儿毛发及母乳中的滥用药物以及乙醇生物标志物而开发的最新分析方法。
