Fillastre C, Brégère P, Guérin N
Centre International de l'Enfance, Paris.
Arch Fr Pediatr. 1989 Nov;46(9):693-700.
Two hundred forty-nine infants were immunized after being randomly allocated to the classical Tetracoq vaccine or to inactivated poliomyelitis vaccines prepared on monkey kidney cells or on Vero-type continuous cell lines either mixed with DPT or placed in a 2-compartment syringe separating (by-pass) the polio vaccine from the DPT. The 3 preparations were well tolerated and led to a good immune response: the first after 3 injections, the second and third after the second injection.
249名婴儿在被随机分配接种经典的Tetracoq疫苗、在猴肾细胞或Vero型连续细胞系上制备的灭活脊髓灰质炎疫苗后进行了免疫接种,这些疫苗要么与百白破混合,要么置于双腔注射器中,将脊髓灰质炎疫苗与百白破分开(旁路)。这三种制剂耐受性良好,并产生了良好的免疫反应:第一次在3次注射后,第二次和第三次在第二次注射后。