Upadhyay J, Kumar A, Gogoi B, Buragohain A K
Department of Physics, Tezpur University, Napaam, Tezpur 784028, Assam, India.
Department of Physics, Tezpur University, Napaam, Tezpur 784028, Assam, India.
Mater Sci Eng C Mater Biol Appl. 2015 Sep;54:8-13. doi: 10.1016/j.msec.2015.04.027. Epub 2015 Apr 22.
Polypyrrole nanotube-silver nanoparticle nanocomposites (PPy-NTs:Ag-NPs) have been synthesized by in-situ reduction of silver nitrate (AgNO3) to suppress the agglomeration of Ag-NPs. The morphology and chemical structure of the nanocomposites have been studied by HRTEM, SEM, XRD, FTIR and UV-vis spectroscopy. The average diameter of the polypyrrole nanotubes (PPy-NTs) is measured to be 130.59±5.5 nm with their length in the micrometer range, while the silver nanoparticles (Ag-NPs) exhibit spherical shape with an average diameter of 23.12±3.23 nm. In-vitro blood compatibility of the nanocomposites has been carried out via hemolysis assay. Antimicrobial activity of the nanocomposites has been investigated with Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria. The results depict that the hemolysis and antimicrobial activities of the nanocomposites increase with increasing Ag-NP concentration that can be controlled by the AgNO3 precursor concentration in the in-situ process.
通过硝酸银（AgNO₃）的原位还原合成了聚吡咯纳米管-银纳米颗粒纳米复合材料（PPy-NTs:Ag-NPs），以抑制银纳米颗粒（Ag-NPs）的团聚。通过高分辨透射电子显微镜（HRTEM）、扫描电子显微镜（SEM）、X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和紫外-可见光谱对纳米复合材料的形态和化学结构进行了研究。测得聚吡咯纳米管（PPy-NTs）的平均直径为130.59±5.5 nm，长度在微米范围内，而银纳米颗粒（Ag-NPs）呈球形，平均直径为23.12±3.23 nm。通过溶血试验对纳米复合材料的体外血液相容性进行了研究。用大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）对纳米复合材料的抗菌活性进行了研究。结果表明，纳米复合材料的溶血和抗菌活性随着Ag-NP浓度的增加而增加，而Ag-NP浓度可通过原位过程中AgNO₃前驱体的浓度来控制。
