5-HTTLPR L/S 多态性与 ADHD 易感性的病例对照和家系研究的荟萃分析。
Meta-Analysis of Case-Control and Family-Based Associations Between the 5-HTTLPR L/S Polymorphism and Susceptibility to ADHD.
机构信息
1 Korea University College of Medicine, Seoul, Korea.
出版信息
J Atten Disord. 2018 Jul;22(9):901-908. doi: 10.1177/1087054715587940. Epub 2015 Jun 5.
OBJECTIVE
The aim of this study was to determine whether the serotonin transporter-linked polymorphic region (5-HTTLPR) L (long)/S (short) polymorphism is associated with susceptibility to ADHD.
METHOD
We conducted a meta-analysis of case-control associations and the transmission disequilibrium test (TDT) between the 5-HTTLPR L/S polymorphism and ADHD.
RESULTS
A total of 19 comparison studies were included in this meta-analysis. Our meta-analysis of the case-control studies showed no association between ADHD and the 5-HTTLPR S allele, for all study participants (odds ratio [OR] = 1.075, 95% confidence interval [CI] = [0.990, 1.167], p = .085), or for the European or Asian population. The TDT indicated no association between ADHD and the 5-HTTLPR S allele, for all study participants (OR = 1.078, 95% CI = [0.962, 1.207], p = .196).
CONCLUSION
This meta-analysis of case-control studies and TDT showed a lack of association between the 5-HTTLPR L/S polymorphism and ADHD.
目的
本研究旨在确定 5-羟色胺转运体相关多态性区域（5-HTTLPR）L（长）/S（短）多态性是否与 ADHD 的易感性相关。
方法
我们对病例对照关联和 5-HTTLPR L/S 多态性与 ADHD 之间的传递不平衡检验（TDT）进行了荟萃分析。
结果
共有 19 项对照研究纳入本荟萃分析。我们对病例对照研究的荟萃分析显示，5-HTTLPR S 等位基因与 ADHD 之间无关联，对于所有研究参与者（比值比[OR] = 1.075，95%置信区间[CI] = [0.990，1.167]，p =.085），或在欧洲或亚洲人群中。TDT 表明 ADHD 与 5-HTTLPR S 等位基因之间无关联，对于所有研究参与者（OR = 1.078，95% CI = [0.962，1.207]，p =.196）。
结论
本病例对照研究和 TDT 的荟萃分析表明，5-HTTLPR L/S 多态性与 ADHD 之间无关联。
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