Department of Otolaryngology-Head and Neck Surgery, Capital Institute of Pediatrics, Beijing, China.
Graduate School of Peking Union Medical College, Beijing, China.
PeerJ. 2024 Oct 18;12:e18287. doi: 10.7717/peerj.18287. eCollection 2024.
Numerous investigations have examined the potential link between allergic rhinitis (AR) and attention deficit hyperactivity disorder (ADHD). However, some studies show no association between the two diseases. The connection between these two conditions remains inconclusive. This study aimed to conduct a meta-analysis exploring the correlation between AR and ADHD.
We conducted systematic searches of the MEDLINE, EMBASE, Cochrane Library, ERIC, PubMed, Web of Science, and CINAHL databases, up to the year 2023. Subsequently, we conducted a meta-analysis using R 4.2.2, where we computed the pooled odds ratio with a 95% confidence interval to assess the relationship between AR and ADHD within studies exhibiting similar characteristics. Statistical heterogeneity was evaluated by computing the value using the Cochrane Intervention Manual's guidelines. Additionally, subgroup analyses were conducted by stratifying the study population according to gender, age, . Sensitivity analysis was performed by systematically removing individual studies.
In this systematic review, we incorporated 12 eligible studies, collectively encompassing a sample size of 530,360 participants. Within the included studies, heterogeneity was observed, and the utilization of a random-effects model demonstrated a noteworthy correlation between children with ADHD and the presence of AR. Similarly, children with AR exhibited a significant correlation with the occurrence of ADHD. We also found some relationships in subgroup analyses.
A substantial correlation is evident between AR and ADHD in children and adolescents. AR may potentially contribute as a risk factor for the onset of ADHD, and conversely, ADHD may heighten the likelihood of developing AR.
许多研究都探讨了过敏性鼻炎（AR）和注意缺陷多动障碍（ADHD）之间的潜在联系。然而，一些研究表明这两种疾病之间没有关联。这两种疾病之间的联系仍不确定。本研究旨在进行荟萃分析，探讨 AR 与 ADHD 之间的相关性。
我们对 MEDLINE、EMBASE、Cochrane 图书馆、ERIC、PubMed、Web of Science 和 CINAHL 数据库进行了系统搜索，截至 2023 年。随后，我们使用 R 4.2.2 进行了荟萃分析，计算了汇总优势比及其 95%置信区间，以评估具有相似特征的研究中 AR 与 ADHD 之间的关系。使用 Cochrane 干预手册指南计算值来评估统计异质性。此外，还根据性别、年龄、. 进行了亚组分析。通过系统地删除个别研究进行敏感性分析。
在这项系统评价中，我们纳入了 12 项符合条件的研究，总共纳入了 530,360 名参与者。在纳入的研究中，存在异质性，使用随机效应模型表明 ADHD 儿童与 AR 存在显著相关性。同样，患有 AR 的儿童与 ADHD 的发生也存在显著相关性。我们还在亚组分析中发现了一些关系。
儿童和青少年中 AR 与 ADHD 之间存在显著相关性。AR 可能是 ADHD 发病的一个潜在危险因素，反之亦然，ADHD 可能会增加患 AR 的可能性。
