Demirtas G S, Akman L, Demirtas O, Hursitoglu B S, Terek M C, Zekioglu O, Yilmaz H, Ozsaran A A
Eur J Gynaecol Oncol. 2015;36(2):150-4.
To evaluate colposcopic biopsy results of patients with cervical cytological findings of atypical squamous cells of undetermined significance (ASC-US) and atypical squamous cells with high-grade lesions that cannot be excluded (ASC-H).
A retrospective evaluation of data from 358 patients, who had cervical cytological findings of ASC-US (n = 335) and ASC-H (n = 23), and had colposcopic assessments between 2005 and 2011.
Cervical biopsy results of patients diagnosed with ASC-US cytology (n = 335) revealed cervical squamous cell carcinoma 0.9 % (n = 3) at biopsy, cervical intraepithelial neoplasia 3 (CIN 3) in 3.8 % (n = 13), cervical intraepithelial neoplasia 2 (CIN 2) in 1.1 % (n = 4), cervical intraepithelial neoplasia 1 (CIN 1) in 35.2% (n = 118), and benign lesions in 59 % (n = 197). Cervical biopsy results of patients diagnosed with ASC-H cytology (n = 23) revealed CIN 3 at biopsy in 39.3% (n = 9), CIN 2 in 21.7% (n = 5), CIN 1 in 26% (n = 6), carcinoma in situ in 8.7% (n = 2), and squamous cell cancer in one patient (4.3%).
The cytological diagnosis of ASC-US may lead to the diagnosis of cervical intraepithelial lesion of higher grades as well as cervical cancer and should be evaluated by colposcopic cervical biopsy.
评估宫颈细胞学检查结果为意义不明确的非典型鳞状细胞（ASC-US）和不能排除高级别病变的非典型鳞状细胞（ASC-H）患者的阴道镜活检结果。
回顾性评估2005年至2011年间358例宫颈细胞学检查结果为ASC-US（n = 335）和ASC-H（n = 23）且接受阴道镜评估患者的数据。
诊断为ASC-US细胞学的患者（n = 335）宫颈活检结果显示，活检时宫颈鳞状细胞癌占0.9%（n = 3），宫颈上皮内瘤变3级（CIN 3）占3.8%（n = 13），宫颈上皮内瘤变2级（CIN 2）占1.1%（n = 4），宫颈上皮内瘤变1级（CIN 1）占35.2%（n = 118），良性病变占59%（n = 197）。诊断为ASC-H细胞学的患者（n = 23）宫颈活检结果显示，活检时CIN 3占39.3%（n = 9），CIN 2占21.7%（n = 5），CIN 1占26%（n = 6），原位癌占8.7%（n = 2），1例患者为鳞状细胞癌（4.3%）。
ASC-US的细胞学诊断可能导致更高等级的宫颈上皮内病变以及宫颈癌的诊断，应通过宫颈阴道镜活检进行评估。
