Sherrill Katherine R, Chrastil Elizabeth R, Ross Robert S, Erdem Uğur M, Hasselmo Michael E, Stern Chantal E
Center for Memory and Brain, Department of Psychological and Brain Sciences, Boston University, Boston, MA 02215, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Department of Psychology, University of New Hampshire, Durham, NH 03824, USA.
Neuroimage. 2015 Sep;118:386-96. doi: 10.1016/j.neuroimage.2015.06.009. Epub 2015 Jun 6.
Recent computational models suggest that visual input from optic flow provides information about egocentric (navigator-centered) motion and influences firing patterns in spatially tuned cells during navigation. Computationally, self-motion cues can be extracted from optic flow during navigation. Despite the importance of optic flow to navigation, a functional link between brain regions sensitive to optic flow and brain regions important for navigation has not been established in either humans or animals. Here, we used a beta-series correlation methodology coupled with two fMRI tasks to establish this functional link during goal-directed navigation in humans. Functionally defined optic flow sensitive cortical areas V3A, V6, and hMT+ were used as seed regions. fMRI data was collected during a navigation task in which participants updated position and orientation based on self-motion cues to successfully navigate to an encoded goal location. The results demonstrate that goal-directed navigation requiring updating of position and orientation in the first person perspective involves a cooperative interaction between optic flow sensitive regions V3A, V6, and hMT+ and the hippocampus, retrosplenial cortex, posterior parietal cortex, and medial prefrontal cortex. These functional connections suggest a dynamic interaction between these systems to support goal-directed navigation.
最近的计算模型表明，来自光流的视觉输入提供了关于自我中心（以导航者为中心）运动的信息，并在导航过程中影响空间调谐细胞的放电模式。从计算角度来看，自我运动线索可以在导航过程中从光流中提取。尽管光流对导航很重要，但在人类或动物中，对光流敏感的脑区与对导航重要的脑区之间的功能联系尚未建立。在这里，我们使用β系列相关方法结合两项功能磁共振成像任务，在人类目标导向导航过程中建立这种功能联系。功能定义的对光流敏感的皮质区域V3A、V6和hMT+被用作种子区域。在一项导航任务中收集功能磁共振成像数据，在该任务中，参与者根据自我运动线索更新位置和方向，以成功导航到编码的目标位置。结果表明，在第一人称视角下需要更新位置和方向的目标导向导航涉及光流敏感区域V3A、V6和hMT+与海马体、压后皮质、顶叶后皮质和内侧前额叶皮质之间的协同相互作用。这些功能连接表明这些系统之间存在动态相互作用以支持目标导向导航。
