Le Ngoc Tho Sandra, Ader Florence, Ferry Tristan, Floret Daniel, Arnal Maximilien, Fargeas Simone, Chidiac Christian, Valour Florent
Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France; Department of General Medicine, Claude Bernard Lyon 1 University, Lyon, France.
Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France; INSERM U1111, International Centre for Research in Infectiology, Claude Bernard Lyon 1 University, Lyon, France.
Vaccine. 2015 Jul 9;33(30):3463-70. doi: 10.1016/j.vaccine.2015.05.073. Epub 2015 Jun 12.
A vaccine against serogroup B Neisseria meningitidis, major cause of bacterial meningitis in children and adults, has recently been developed. In a context of an increasing parental mistrust against vaccinations, understanding the reason for their choices is crucial in order to improve immunization coverage. Our study aimed at evaluating parental attitudes and perceptions towards serogroup B meningococcal invasive disease vaccination.
A prospective observational study was conducted in different French independent-practice medical offices (general practitioners and paediatricians) and nurseries between May 1 and December 31, 2013, using a questionnaire distributed in electronic and paper forms to parents having at least one child between the ages of 2 months and 16 years old.
1270 parents were included, of whom 671 (52.8%) spontaneously stated to be in favour of this vaccination. Their choice was mainly justified by the severity of the disease (63.8%) and the desire to protect their child (51.7%). In multivariate analysis, the young age of parents (OR 0.949 per additional year; p<10(-3)), the history of vaccination against serogroup C meningococcal invasive diseases (OR 6.755; p<10(-3)), and the prior knowledge of the vaccine (OR 2.081; p=0.001) were associated with vaccination acceptance. The main reasons for refusal were the lack of hindsight on this new vaccine (50.6%) and the fear of side effects (45.5%). After objective information on the disease and the vaccine, only 6.3% of the entire responding population would refuse to consider vaccination.
The spontaneous acceptance rate of vaccination against serogroup B meningococcal invasive disease is insufficient. However, after objective information by their physician or public health authorities, only a few parents would in the end be completely resistant.
B 群脑膜炎奈瑟菌是儿童和成人细菌性脑膜炎的主要病因，针对该病菌的疫苗最近已研发出来。在家长对疫苗接种的不信任日益增加的背景下，了解他们做出选择的原因对于提高免疫接种覆盖率至关重要。我们的研究旨在评估家长对 B 群脑膜炎球菌侵袭性疾病疫苗接种的态度和看法。
2013 年 5 月 1 日至 12 月 31 日期间，在法国不同的独立执业医疗办公室（全科医生和儿科医生）及托儿所开展了一项前瞻性观察研究，通过电子和纸质形式向至少有一名年龄在 2 个月至 16 岁之间孩子的家长发放问卷。
共纳入 1270 名家长，其中 671 名（52.8%）自发表示赞成这种疫苗接种。他们做出选择的主要理由是疾病的严重性（63.8%）以及保护孩子的愿望（51.7%）。多因素分析显示，家长年龄较小（每增加一岁，比值比为 0.949；p<10⁻³）、有 C 群脑膜炎球菌侵袭性疾病疫苗接种史（比值比为 6.755；p<10⁻³）以及对疫苗的预先了解（比值比为 2.081；p = 0.001）与疫苗接种接受度相关。拒绝接种的主要原因是对这种新疫苗缺乏经验（50.6%）以及担心副作用（45.5%）。在获得关于疾病和疫苗的客观信息后，整个应答人群中只有 6.3%的人会拒绝考虑接种疫苗。
B 群脑膜炎球菌侵袭性疾病疫苗接种的自发接受率不足。然而，在医生或公共卫生当局提供客观信息后，最终只有少数家长会完全抗拒。
