Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), 28040 Madrid, Spain.
Virus Res. 2015 Nov 2;209:118-27. doi: 10.1016/j.virusres.2015.05.026. Epub 2015 Jun 7.
Viruses are strict intracellular pathogens that require the cellular environment to complete a successful infection. Among them, African swine fever virus (ASFV) is an evolutionary ancient DNA virus, endemic in Africa, which is nowadays causing an emergent disease in Europe with a potential high economic impact in the pig industry. It is well known that host-cell components are critical crossroads mapping the virus path for a productive infection, some of them at the endocytic pathway. Considering that ASFV infectious cycle strongly relies in several factors from the host cell, the study of virus-host interactions remains crucial as they will reveal the obstacles, routes and tracks, hints and the target waypoint in the virus journey to destination.
病毒是严格的细胞内病原体，需要细胞环境才能完成成功的感染。其中，非洲猪瘟病毒（ASFV）是一种进化古老的 DNA 病毒，在非洲流行，如今在欧洲引发了一种突发疾病，对养猪业可能产生重大经济影响。众所周知，宿主细胞成分是病毒进行有效感染的关键交汇点，其中一些位于内吞作用途径。鉴于 ASFV 的感染周期强烈依赖宿主细胞的几个因素，研究病毒-宿主相互作用仍然至关重要，因为它们将揭示病毒到达目的地的障碍、途径和轨迹、线索以及目标途径。
