富血小板血浆与脱蛋白牛骨基质在上颌窦提升术中的应用：一项双侧对照组织形态计量学评估
Platelet-Rich Plasma and Deproteinized Bovine Bone Matrix in Maxillary Sinus Lift Surgery: A Split-Mouth Histomorphometric Evaluation.
作者信息
Taschieri Silvio, Testori Tiziano, Corbella Stefano, Weinstein Roberto, Francetti Luca, Di Giancamillo Alessia, Del Fabbro Massimo
机构信息
*Academic Researcher, Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy; Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Member Oral Health Research Centre, Milan, Italy. †Visiting Professor, Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Milan, Italy. ‡Visiting Professor, Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Member Oral Implantology Research Centre, Milan, Italy. §Full Professor, Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy; Head of Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Member Oral Health Research Centre, Milan, Italy. ¶Associate Professor, Director Oral Implantology Research Centre, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Department of Biomedical, Surgical and Dental Sciences, Director Oral Implantology Research Centre, Milan, Italy. ‖Visiting Professor, Department of Health, Animal Science and Food Safety, Milan, Italy. #Associate Professor, Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy; Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Director Oral Health Research Centre, Milan, Italy.
出版信息
Implant Dent. 2015 Oct;24(5):592-7. doi: 10.1097/ID.0000000000000293.
PURPOSE
The purpose of this split-mouth controlled study was to evaluate and compare the amount of vital bone after lateral sinus lift surgery using either a mixture of pure platelet concentrate and deproteinized bovine bone mineral (test group) or solely deproteinized bovine bone as grafting material (control group).
MATERIALS AND METHODS
Six patients with edentulous posterior maxilla and a residual ridge height of less than 4 mm were recruited in this study. Six months after grafting procedure, 2 bone biopsies per patient were taken bilaterally from the anterolateral sinus wall. Histological and histomorphometrical analysis was carried out.
RESULTS
A total of 10 sinus surgeries in 5 patients were analyzed. The mean percentage of vital bone was 22.72% ± 9.21% (range, 11.45%-33.30%) in the control group and 30.70% ± 7.89% (range, 18.30%-39.99%) in the test group.
CONCLUSION
The adjunct of pure platelet-rich plasma to deproteinized bovine bone mineral may enhance vital bone formation in the first 6 months after sinus floor augmentation. However, no statistically significant difference was found between groups (P = 0.18).
目的
本双盲对照研究旨在评估和比较使用纯血小板浓缩物与脱蛋白牛骨矿物质的混合物（试验组）或仅使用脱蛋白牛骨作为移植材料（对照组）进行外侧上颌窦提升术后的活性骨量。
材料与方法
本研究招募了6例上颌后牙区无牙且剩余牙槽嵴高度小于4mm的患者。在植骨手术后6个月，从每位患者双侧的前外侧窦壁取2块骨活检样本。进行组织学和组织形态计量学分析。
结果
共分析了5例患者的10次鼻窦手术。对照组活性骨的平均百分比为22.72%±9.21%（范围为11.45%-33.30%），试验组为30.70%±7.89%（范围为18.30%-39.99%）。
结论
在脱蛋白牛骨矿物质中添加纯富血小板血浆可能会在窦底增高术后的前6个月增强活性骨形成。然而，两组之间未发现统计学上的显著差异（P = 0.18）。
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