Acharyya Bhaswati C, Bhattacharyya Chandrayee, Mukhopadhyay Meghdeep, Acharyya Saumyabrata
Division of Paediatric Gastroenterology, AMRI Hospitals, Kolkata, India.
Division of Paediatrics, Apollo Gleneagles Hospital, Kolkata, India.
Pediatr Gastroenterol Hepatol Nutr. 2021 Mar;24(2):230-237. doi: 10.5223/pghn.2021.24.2.230. Epub 2021 Mar 4.
Functional constipation is common in the paediatric population all over the world. Effective disimpaction to evacuate the impacted faecal matter forms an essential initial step in the management of constipation. Though different regimens of polyethylene glycol 3350 with electrolytes (PEG+E) are accepted as the prime medication for disimpaction, response is not always satisfactory. A randomised prospective study was undertaken, in a tertiary paediatric Gastroenterology centre to find out the outcome of a 2-day disimpaction when a stimulant laxative sodium picosulphate was added to PEG3350+E (PEG+E+PS group) and comparing it with the outcome using PEG3350+E (PEG+E group) alone. Hundred and one children were randomised into two groups to receive PEG+E+PS and PEG+E. Results revealed that PEG+E+PS group proved significantly superior to PEG+E group in most of the efficacy-parameters in terms of disimpaction as well as long-term management of constipation. Though stimulant laxatives are being used for disimpaction, comparative data are lacking. This was the 1st such comparative study looking at the efficacy of these two processes of disimpaction along with long term effect on treatment.
功能性便秘在世界各地的儿科人群中都很常见。有效解除粪便嵌塞以排出嵌塞的粪便，是便秘管理中必不可少的初始步骤。尽管不同配方的聚乙二醇3350加电解质（PEG+E）被公认为解除粪便嵌塞的主要药物，但效果并不总是令人满意。在一家三级儿科胃肠病中心进行了一项随机前瞻性研究，以探究在PEG3350+E中添加刺激性泻药比沙可啶钠进行为期2天的粪便嵌塞解除的效果，并将其与单独使用PEG3350+E（PEG+E组）的效果进行比较。101名儿童被随机分为两组，分别接受PEG+E+PS和PEG+E。结果显示, 在粪便嵌塞解除以及便秘的长期管理方面，PEG+E+PS组在大多数疗效参数上均显著优于PEG+E组。尽管刺激性泻药被用于解除粪便嵌塞，但缺乏对比数据。这是第一项比较这两种解除粪便嵌塞方法的疗效以及长期治疗效果的研究。
