Koek Wouter, Gerak Lisa R, France Charles P
Departments of aPsychiatry bPharmacology, University of Texas Health Science Center, San Antonio, Texas, USA.
Behav Pharmacol. 2015 Aug;26(5):481-4. doi: 10.1097/FBP.0000000000000146.
In humans, impulsivity measured as false alarms in a Go/No-Go task is reportedly decreased by amphetamine and is not affected by oxycodone and delta(9)-tetrahydrocannabinol. To model these findings in animals, three rhesus monkeys were trained to perform a food-reinforced Go/No-Go task. In this task, amphetamine was found to decrease false alarms (i.e. responding during No-Go trials), but only at doses that also decreased hits (i.e. responding during Go trials). Morphine generally decreased hits but not false alarms. The cannabinoid receptor agonist CP 55, 940 decreased both false alarms and hits, but only at doses that also decreased the number of trials completed. Additional studies in animals and humans are necessary to delineate the conditions under which amphetamine and other psychoactive drugs affect impulsivity in Go/No-Go tasks.
据报道，在人类中，以“Go/No-Go任务”中的误报衡量的冲动性会因苯丙胺而降低，且不受羟考酮和δ-9-四氢大麻酚影响。为在动物中模拟这些发现，训练了三只恒河猴执行食物强化的“Go/No-Go任务”。在该任务中，发现苯丙胺会减少误报（即在“不执行”试验期间做出反应），但仅在也会减少命中数（即在“执行”试验期间做出反应）的剂量下才会如此。吗啡通常会减少命中数，但不会减少误报。大麻素受体激动剂CP 55,940会同时减少误报和命中数，但同样仅在也会减少完成试验次数的剂量下才会如此。有必要在动物和人类中开展更多研究，以明确苯丙胺和其他精神活性药物在“Go/No-Go任务”中影响冲动性的条件。
