Zacny James P, de Wit Harriet
Department of Anesthesia and Critical Care, MC4028, The University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.
Pharmacol Biochem Behav. 2009 Nov;94(1):108-13. doi: 10.1016/j.pbb.2009.07.010. Epub 2009 Aug 4.
This study examined the effects of oral oxycodone, a prescription opioid, on several measures of impulsive behavior in healthy volunteers. Volunteers (n=12) participated in a four-session, double-blind, randomized design in which they received capsules containing oxycodone (5, 10, and 20 mg) or placebo. From 70 min to approximately 120 min after ingesting the capsules, subjects completed five impulsivity tasks: delay and probability discounting task, balloon analogue risk task (BART), go/no-go task, stop task, and simple reaction time test. Mood questionnaires were also completed at fixed time points in the sessions. Oxycodone produced prototypic changes in mood in a dose-related manner, but did not affect performance on any of the impulsivity tasks. Lack of effect on impulsivity stands in contrast to other studies in which other psychoactive drugs including ethanol, delta-9-tetrahydrocannabinol, and amphetamine altered behavior on one or more behavioral measures of impulsivity.
本研究考察了处方阿片类药物口服羟考酮对健康志愿者多种冲动行为指标的影响。志愿者（n = 12）参与了一项四阶段双盲随机设计，在此过程中他们服用了含有羟考酮（5毫克、10毫克和20毫克）或安慰剂的胶囊。在摄入胶囊后70分钟至约120分钟期间，受试者完成了五项冲动性任务：延迟和概率折扣任务、气球模拟风险任务（BART）、停止信号任务、停止任务和简单反应时间测试。在各阶段的固定时间点还完成了情绪问卷。羟考酮以剂量相关的方式引起了典型的情绪变化，但并未影响任何冲动性任务的表现。对冲动性缺乏影响与其他研究形成对比，在其他研究中，包括乙醇、δ-9-四氢大麻酚和苯丙胺在内的其他精神活性药物改变了一项或多项冲动行为指标的行为表现。
