Chaudhary Arpana S, Chen Weixuan, Jin Jinshan, Tai Phang C, Wang Binghe
Department of Chemistry, Center for Diagnostics & Therapeutics, & Center for Biotechnology & Drug Design, Georgia State University, Atlanta, GA 30303, USA.
Department of Biology, Center for Diagnostics & Therapeutics, & Center for Biotechnology & Drug Design, Georgia State University, Atlanta, GA 30303, USA.
Future Med Chem. 2015;7(8):989-1007. doi: 10.4155/fmc.15.42.
There is a consensus in the medical profession of the pressing need for novel antimicrobial agents due to issues related to drug resistance. In practice, solutions to this problem to a large degree lie with the identification of new and vital targets in bacteria and subsequently designing their inhibitors. We consider SecA a very promising antimicrobial target. In this review, we compile and analyze information available on SecA to show that inhibition of SecA has a multitude of consequences. Furthermore, we discuss issues critical to the design and evaluation of SecA inhibitors.
由于耐药性问题，医学界已达成共识，迫切需要新型抗菌药物。实际上，解决这一问题的方法在很大程度上在于确定细菌中新的关键靶点，并随后设计其抑制剂。我们认为SecA是一个非常有前景的抗菌靶点。在本综述中，我们收集并分析了有关SecA的现有信息，以表明抑制SecA会产生多种后果。此外，我们还讨论了SecA抑制剂设计和评估的关键问题。
