Platt Daniel E, Hariri Essa, Salameh Pascale, Merhi Mahmoud, Sabbah Nada, Helou Mariana, Mouzaya Francis, Nemer Rita, Al-Sarraj Yasser, El-Shanti Hatem, Abchee Antoine B, Zalloua Pierre A
Bioinformatics and Pattern Discovery, IBM T. J. Watson Research Centre, Yorktown Hgts, NY 10598 USA.
School of Medicine, Lebanese American University, Chouran, Beirut, 1102 2801 Lebanon.
Diabetol Metab Syndr. 2017 Mar 21;9:19. doi: 10.1186/s13098-017-0218-0. eCollection 2017.
Elevated homocysteine (Hc) levels have a well-established and clear causal relationship to epithelial damage leading to coronary artery disease. Furthermore, it is strongly associated with other metabolic syndrome variables, such as hypertension, which is correlated with type II diabetes mellitus (T2DM). Studies on T2DM in relation to Hc levels have shown both positive and negative associations. The aim of the present study is to examine the relationship between Hc levels and risk of T2DM in the Lebanese population.
We sought to identify whether Hc associates positively or negatively with diabetes in a case-control study, where 2755 subjects enrolled from patients who had been catheterized for coronary artery diagnosis and treatment. We further sought to identify whether the gene variant MTHFR 667C>T is associated with T2DM, and how Hc and MTHFR 667C>T also impact other correlates of T2DM, including the widely used diuretics in this study population.
We found that Hc levels were significantly reduced among subjects with diabetes compared to those without diabetes when adjusted for all potential confounders (OR 0.640; 95% CI [0.44-0.92]; = 0.0200). The associations between Hc levels and other variates contradicted the result: hypertension associates positively with high Hc levels, and with T2DM. The MTHFR 667C>T only associated significantly with high Hc levels.
These results suggest population-specific variations among a range of mechanisms that modulate the association of Hc and T2DM, providing a probe for future studies.
同型半胱氨酸（Hc）水平升高与导致冠状动脉疾病的上皮损伤存在明确且已确立的因果关系。此外，它还与其他代谢综合征变量密切相关，如与II型糖尿病（T2DM）相关的高血压。关于T2DM与Hc水平的研究呈现出正相关和负相关两种情况。本研究的目的是探讨黎巴嫩人群中Hc水平与T2DM风险之间的关系。
在一项病例对照研究中，我们试图确定Hc与糖尿病之间是正相关还是负相关，该研究纳入了2755名因冠状动脉诊断和治疗而接受导管插入术的患者。我们还试图确定基因变体MTHFR 667C>T是否与T2DM相关，以及Hc和MTHFR 667C>T如何影响T2DM的其他相关因素，包括本研究人群中广泛使用的利尿剂。
在对所有潜在混杂因素进行校正后，我们发现糖尿病患者的Hc水平显著低于非糖尿病患者（OR 0.640；95% CI [0.44 - 0.92]；P = 0.0200）。Hc水平与其他变量之间的关联与该结果相矛盾：高血压与高Hc水平以及T2DM呈正相关。MTHFR 667C>T仅与高Hc水平显著相关。
这些结果表明，在一系列调节Hc与T2DM关联的机制中存在人群特异性差异，为未来的研究提供了一个探索方向。
