Merkx J, Slob A K, van der Werff ten Bosch J J
Department of Endocrinology, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands.
Horm Behav. 1989 Dec;23(4):466-72. doi: 10.1016/0018-506x(89)90036-6.
The effects were studied of long-term treatment with testosterone metabolites (dihydrotestosterone. DHT, and estradiol, E2, in sc Silastic implants) on preference behavior of ovariectomized female rats for an estrous female over a non-estrous female. For measuring this behavior a residential plus-maze was used which harbored two ovariectomized "stimulus" females on the top of peripheral boxes, one of which was made estrus by injection of estradiol benzoate and progesterone. When both steroids (DHT plus E2) were circulating simultaneously they evoked preference for an estrous female, while neither steroid by itself sufficed. In earlier work with adult male rats castrated on the day of birth, E2 was effective in the absence of DHT. This sex difference, therefore, seems to have arisen before birth. Further, administration of DHT alone caused a profound lack of interest in both "stimulus" females, which cannot be fully explained by the reduced locomotor activity which has been found to be induced by DHT in earlier studies.
研究了用睾酮代谢物（二氢睾酮，DHT，以及雌二醇，E2，通过皮下硅橡胶植入物）长期治疗对卵巢切除的雌性大鼠在有发情期雌鼠和非发情期雌鼠之间偏好行为的影响。为了测量这种行为，使用了一个居住型十字迷宫，在外围盒子顶部有两只卵巢切除的“刺激”雌鼠，其中一只通过注射苯甲酸雌二醇和孕酮进入发情期。当两种类固醇（DHT加E2）同时循环时，它们会引起对发情期雌鼠的偏好，而单独一种类固醇都不足以产生这种效果。在早期对出生当天阉割的成年雄性大鼠的研究中，E2在没有DHT的情况下是有效的。因此，这种性别差异似乎在出生前就已经出现。此外，单独给予DHT会导致对两只“刺激”雌鼠都极度缺乏兴趣，这不能完全用早期研究中发现的DHT诱导的运动活动减少来解释。
