Wang D, Zhai J X, Zhang L M, Liu D W, Liu X H
Mol Biol (Mosk). 2015 Mar-Apr;49(2):351-61. doi: 10.7868/s0026898415020160.
To clarify the association between microsomal epoxide hydrolase gene (EPHX1) Tyr113His polymorphism and hepatocellular carcinoma (HCC) risk, a meta-analysis was performed. Overall, EPHX1 Tyr113His polymorphism was associated with increased risk of HCC. Subgroup analyses by status of Hardy-Weinberg equilibrium (HWE) in controls further confirmed this association. Through a literature search, 119 relevant records were identified, and 17 individual case-control studies from 13 publications were finally included, involving a total of 1,480 HCC cases and 2,564 controls. In subgroup analyses, increased associations were found in Asians, Caucasians, hepatitis B virus (HBV)- dominant areas, hepatitis C virus (HCV)-dominant areas, high-rate areas of HCC, and medium-rate areas of HCC, but not in Africans and low-rate areas of HCC, respectively. This meta-analysis suggests that EPHX1 Tyr113His polymorphism contributes to HCC risk.
为阐明微粒体环氧化物水解酶基因（EPHX1）Tyr113His多态性与肝细胞癌（HCC）风险之间的关联，进行了一项荟萃分析。总体而言，EPHX1 Tyr113His多态性与HCC风险增加相关。通过对对照组中哈迪-温伯格平衡（HWE）状态进行亚组分析，进一步证实了这种关联。通过文献检索，共识别出119条相关记录，最终纳入了来自13篇出版物的17项个体病例对照研究，总共涉及1480例HCC病例和2564例对照。在亚组分析中，分别在亚洲人、高加索人、乙型肝炎病毒（HBV）为主的地区、丙型肝炎病毒（HCV）为主的地区、HCC高发地区和HCC中发地区发现关联增加，但在非洲人和HCC低发地区未发现。这项荟萃分析表明，EPHX1 Tyr113His多态性会增加HCC风险。
