Foster D M, Boston R C, Jacquez J A, Zech L
Center for Bioengineering, University of Washington, Seattle 98195.
Health Phys. 1989;57 Suppl 1:457-66. doi: 10.1097/00004032-198907001-00063.
Kinetic analysis and integrated system modeling have contributed significantly to understanding the physiology and pathophysiology of metabolic systems in humans and animals. Many experimental biologists are aware of the usefulness of these techniques and recognize that kinetic modeling requires special expertise. The Resource Facility for Kinetic Analysis (RFKA) provides this expertise through: (1) development and application of modeling technology for biomedical problems, and (2) development of computer-based kinetic modeling methodologies concentrating on the computer program Simulation, Analysis, and Modeling (SAAM) and its conversational version, CONversational SAAM (CONSAM). The RFKA offers consultation to the biomedical community in the use of modeling to analyze kinetic data and trains individuals in using this technology for biomedical research. Early versions of SAAM were widely applied in solving dosimetry problems; many users, however, are not familiar with recent improvements to the software. The purpose of this paper is to acquaint biomedical researchers in the dosimetry field with RFKA, which, together with the joint National Cancer Institute-National Heart, Lung and Blood Institute project, is overseeing SAAM development and applications. In addition, RFKA provides many service activities to the SAAM user community that are relevant to solving dosimetry problems.
动力学分析和集成系统建模在理解人类和动物代谢系统的生理学和病理生理学方面发挥了重要作用。许多实验生物学家都意识到这些技术的实用性，并认识到动力学建模需要特殊的专业知识。动力学分析资源设施（RFKA）通过以下方式提供这种专业知识：（1）开发和应用针对生物医学问题的建模技术，以及（2）开发以计算机程序模拟、分析和建模（SAAM）及其对话版本对话式SAAM（CONSAM）为核心的基于计算机的动力学建模方法。RFKA就使用建模分析动力学数据向生物医学领域提供咨询，并培训个人将该技术用于生物医学研究。SAAM的早期版本广泛应用于解决剂量测定问题；然而，许多用户并不熟悉该软件的最新改进。本文的目的是让剂量测定领域的生物医学研究人员了解RFKA，RFKA与美国国家癌症研究所 - 国家心肺血液研究所的联合项目一起，正在监督SAAM的开发和应用。此外，RFKA为SAAM用户社区提供了许多与解决剂量测定问题相关的服务活动。
