Barrett P H, Bell B M, Cobelli C, Golde H, Schumitzky A, Vicini P, Foster D M
Department of Bioengineering, University of Washington, Seattle 98195-2255, USA.
Metabolism. 1998 Apr;47(4):484-92. doi: 10.1016/s0026-0495(98)90064-6.
Kinetic analysis and integrated systems modeling have contributed substantially to our understanding of the physiology and pathophysiology of metabolic systems and the distribution and clearance of drugs in humans and animals. In recent years, many researchers have become aware of the usefulness of these techniques in the experimental design. With this has come the recognition that the discipline of kinetic analysis requires its own expertise. The expertise can impact experimental design in many ways, from the collaborative and service activities in which individuals interact in formal ways to the development of software tools to aid in kinetic analysis. The purpose of this report is to describe one such software tool, Simulation, Analysis, and Modeling Software II (SAAM II). In the first part, we describe in general how the user can take advantage of the capabilities of the software system, and in the second part, we give three specific examples using multicompartmental models found in lipoprotein (apolipoprotein B [apoB] kinetics) and diabetes (glucose minimal model) research.
动力学分析和综合系统建模极大地促进了我们对代谢系统的生理学和病理生理学，以及药物在人和动物体内的分布与清除的理解。近年来，许多研究人员已经意识到这些技术在实验设计中的实用性。随之而来的是认识到动力学分析学科需要其自身的专业知识。这种专业知识可以在许多方面影响实验设计，从个体以正式方式进行互动的协作和服务活动，到有助于动力学分析的软件工具的开发。本报告的目的是描述一种这样的软件工具，即模拟、分析和建模软件II（SAAM II）。在第一部分，我们总体描述用户如何利用该软件系统的功能，在第二部分，我们给出三个具体例子，这些例子使用了脂蛋白（载脂蛋白B [apoB]动力学）和糖尿病（葡萄糖最小模型）研究中的多室模型。
